Update: Acute coronary syndromes (V). Personalized antiplatelet therapy.

Journal Article (Journal Article;Review)

It is well established that high on-treatment platelet reactivity to adenosine diphosphate during clopidogrel therapy is an independent risk factor for ischemic event occurrences in a postpercutaneous coronary intervention patients. However, the precise role of platelet function testing remains debated. Platelet function testing to ensure optimal platelet inhibition has been recommended by some authorities to improve outcomes in patients treated with clopidogrel. Recent prospective, randomized trials of personalized antiplatelet therapy have failed to demonstrate a benefit of platelet function testing in improving outcomes. In this review article, we discuss the mechanisms responsible for clopidogrel nonreponsiveness, recent trials of platelet function testing, and other new developments in the field of personalized antiplatelet therapy.

Full Text

Duke Authors

Cited Authors

  • Gurbel, PA; Rafeedheen, R; Tantry, US

Published Date

  • June 2014

Published In

Volume / Issue

  • 67 / 6

Start / End Page

  • 480 - 487

PubMed ID

  • 24863597

Electronic International Standard Serial Number (EISSN)

  • 1885-5857

Digital Object Identifier (DOI)

  • 10.1016/j.rec.2014.01.012


  • eng

Conference Location

  • Spain