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Short-course versus long-course chemoradiation in rectal cancer--time to change strategies?

Publication ,  Journal Article
Palta, M; Willett, CG; Czito, BG
Published in: Curr Treat Options Oncol
September 2014

There is significant debate regarding the optimal neoadjuvant regimen for resectable rectal cancer patients. Short-course radiotherapy, a standard approach throughout most of northern Europe, is generally defined as 25 Gy in 5 fractions over the course of 1 week without the concurrent administration of chemotherapy. Long-course radiotherapy is typically defined as 45 to 50.4 Gy in 25-28 fractions with the administration of concurrent 5-fluoropyrimidine-based chemotherapy and is the standard approach in other parts of Europe and the United States. At present, two randomized trials have compared outcomes for short course radiotherapy with long-course chemoradiation showing no difference in respective study endpoints. Late toxicity data are lacking given limited follow-up. Although the ideal neoadjuvant regimen is controversial, our current bias is long-course chemoradiation to treat patients with locally advanced, resectable rectal cancer.

Duke Scholars

Published In

Curr Treat Options Oncol

DOI

EISSN

1534-6277

Publication Date

September 2014

Volume

15

Issue

3

Start / End Page

421 / 428

Location

United States

Related Subject Headings

  • Time Factors
  • Rectal Neoplasms
  • Oncology & Carcinogenesis
  • Neoadjuvant Therapy
  • Humans
  • Combined Modality Therapy
  • Chemoradiotherapy
  • 3211 Oncology and carcinogenesis
 

Citation

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MLA
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Palta, M., Willett, C. G., & Czito, B. G. (2014). Short-course versus long-course chemoradiation in rectal cancer--time to change strategies? Curr Treat Options Oncol, 15(3), 421–428. https://doi.org/10.1007/s11864-014-0296-2
Palta, Manisha, Christopher G. Willett, and Brian G. Czito. “Short-course versus long-course chemoradiation in rectal cancer--time to change strategies?Curr Treat Options Oncol 15, no. 3 (September 2014): 421–28. https://doi.org/10.1007/s11864-014-0296-2.
Palta M, Willett CG, Czito BG. Short-course versus long-course chemoradiation in rectal cancer--time to change strategies? Curr Treat Options Oncol. 2014 Sep;15(3):421–8.
Palta, Manisha, et al. “Short-course versus long-course chemoradiation in rectal cancer--time to change strategies?Curr Treat Options Oncol, vol. 15, no. 3, Sept. 2014, pp. 421–28. Pubmed, doi:10.1007/s11864-014-0296-2.
Palta M, Willett CG, Czito BG. Short-course versus long-course chemoradiation in rectal cancer--time to change strategies? Curr Treat Options Oncol. 2014 Sep;15(3):421–428.
Journal cover image

Published In

Curr Treat Options Oncol

DOI

EISSN

1534-6277

Publication Date

September 2014

Volume

15

Issue

3

Start / End Page

421 / 428

Location

United States

Related Subject Headings

  • Time Factors
  • Rectal Neoplasms
  • Oncology & Carcinogenesis
  • Neoadjuvant Therapy
  • Humans
  • Combined Modality Therapy
  • Chemoradiotherapy
  • 3211 Oncology and carcinogenesis