Comparative definitions for moderate-severe ischemia in stress nuclear, echocardiography, and magnetic resonance imaging.

Journal Article (Journal Article;Review)

The lack of standardized reporting of the magnitude of ischemia on noninvasive imaging contributes to variability in translating the severity of ischemia across stress imaging modalities. We identified the risk of coronary artery disease (CAD) death or myocardial infarction (MI) associated with ≥10% ischemic myocardium on stress nuclear imaging as the risk threshold for stress echocardiography and cardiac magnetic resonance. A narrative review revealed that ≥10% ischemic myocardium on stress nuclear imaging was associated with a median rate of CAD death or MI of 4.9%/year (interquartile range: 3.75% to 5.3%). For stress echocardiography, ≥3 newly dysfunctional segments portend a median rate of CAD death or MI of 4.5%/year (interquartile range: 3.8% to 5.9%). Although imprecisely delineated, moderate-severe ischemia on cardiac magnetic resonance may be indicated by ≥4 of 32 stress perfusion defects or ≥3 dobutamine-induced dysfunctional segments. Risk-based thresholds can define equivalent amounts of ischemia across the stress imaging modalities, which will help to translate a common understanding of patient risk on which to guide subsequent management decisions.

Full Text

Duke Authors

Cited Authors

  • Shaw, LJ; Berman, DS; Picard, MH; Friedrich, MG; Kwong, RY; Stone, GW; Senior, R; Min, JK; Hachamovitch, R; Scherrer-Crosbie, M; Mieres, JH; Marwick, TH; Phillips, LM; Chaudhry, FA; Pellikka, PA; Slomka, P; Arai, AE; Iskandrian, AE; Bateman, TM; Heller, GV; Miller, TD; Nagel, E; Goyal, A; Borges-Neto, S; Boden, WE; Reynolds, HR; Hochman, JS; Maron, DJ; Douglas, PS; National Institutes of Health/National Heart, Lung, and Blood Institute-Sponsored ISCHEMIA Trial Investigators,

Published Date

  • June 2014

Published In

Volume / Issue

  • 7 / 6

Start / End Page

  • 593 - 604

PubMed ID

  • 24925328

Pubmed Central ID

  • PMC4128344

Electronic International Standard Serial Number (EISSN)

  • 1876-7591

Digital Object Identifier (DOI)

  • 10.1016/j.jcmg.2013.10.021


  • eng

Conference Location

  • United States