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Dual-energy micro-CT imaging of pulmonary airway obstruction: Correlation with micro-SPECT

Publication ,  Conference
Badea, CT; Befera, N; Clark, D; Qi, Y; Johnson, GA
Published in: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
January 1, 2014

To match recent clinical dual energy (DE) CT studies focusing on the lung, similar developments for DE micro-CT of the rodent lung are required. Our group has been actively engaged in designing pulmonary gating techniques for micro- CT, and has also introduced the first DE micro-CT imaging method of the rodent lung. The aim of this study was to assess the feasibility of DE micro-CT imaging for the evaluation of airway obstruction in mice, and to compare the method with micro single photon emission computed tomography (micro-SPECT) using technetium-99m labeled macroaggregated albumin (99mTc-MAA). The results suggest that the induced pulmonary airway obstruction causes either atelectasis, or air-trapping similar to asthma or chronic bronchitis. Atelectasis could only be detected at early time points in DE micro-CT images, and is associated with a large increase in blood fraction and decrease in air fraction. Air trapping had an opposite effect with larger air fraction and decreased blood fraction shown by DE micro-CT. The decrease in perfusion to the hypoventilated lung (hypoxic vasoconstriction) is also seen in micro-SPECT. The proposed DE micro-CT technique for imaging localized airway obstruction performed well in our evaluation, and provides a higher resolution compared to micro-SPECT. Both DE micro-CT and micro-SPECT provide critical, quantitative lung biomarkers for image-based anatomical and functional information in the small animal. The methods are readily linked to clinical methods allowing direct comparison of preclinical and clinical results. © 2014 SPIE.

Duke Scholars

Published In

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

DOI

ISSN

1605-7422

ISBN

9780819498311

Publication Date

January 1, 2014

Volume

9038
 

Citation

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Badea, C. T., Befera, N., Clark, D., Qi, Y., & Johnson, G. A. (2014). Dual-energy micro-CT imaging of pulmonary airway obstruction: Correlation with micro-SPECT. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 9038). https://doi.org/10.1117/12.2043094
Badea, C. T., N. Befera, D. Clark, Y. Qi, and G. A. Johnson. “Dual-energy micro-CT imaging of pulmonary airway obstruction: Correlation with micro-SPECT.” In Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol. 9038, 2014. https://doi.org/10.1117/12.2043094.
Badea CT, Befera N, Clark D, Qi Y, Johnson GA. Dual-energy micro-CT imaging of pulmonary airway obstruction: Correlation with micro-SPECT. In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2014.
Badea, C. T., et al. “Dual-energy micro-CT imaging of pulmonary airway obstruction: Correlation with micro-SPECT.” Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9038, 2014. Scopus, doi:10.1117/12.2043094.
Badea CT, Befera N, Clark D, Qi Y, Johnson GA. Dual-energy micro-CT imaging of pulmonary airway obstruction: Correlation with micro-SPECT. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2014.

Published In

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

DOI

ISSN

1605-7422

ISBN

9780819498311

Publication Date

January 1, 2014

Volume

9038