The inextricable role of the kidney in hypertension.

Journal Article (Journal Article;Review)

An essential link between the kidney and blood pressure control has long been known. Here, we review evidence supporting the premise that an impaired capacity of the kidney to excrete sodium in response to elevated blood pressure is a major contributor to hypertension, irrespective of the initiating cause. In this regard, recent work suggests that novel pathways controlling key sodium transporters in kidney epithelia have a critical impact on hypertension pathogenesis, supporting a model in which impaired renal sodium excretion is a final common pathway through which vascular, neural, and inflammatory responses raise blood pressure. We also address recent findings calling into question long-standing notions regarding the relationship between sodium intake and changes in body fluid volume. Expanded understanding of the role of the kidney as both a cause and target of hypertension highlights key aspects of pathophysiology and may lead to identification of new strategies for prevention and treatment.

Full Text

Duke Authors

Cited Authors

  • Coffman, TM

Published Date

  • June 2014

Published In

Volume / Issue

  • 124 / 6

Start / End Page

  • 2341 - 2347

PubMed ID

  • 24892708

Pubmed Central ID

  • PMC4092877

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

Digital Object Identifier (DOI)

  • 10.1172/JCI72274


  • eng

Conference Location

  • United States