Travelers with sickle cell disease.

Journal Article (Journal Article;Review)

BACKGROUND: Sickle cell disease (SCD) is the most common genetic disease among persons with African ancestry. This article provides a background to SCD and reviews many important aspects of travel preparation in this population. METHODS: The medical literature was searched for studies on travel-associated preparedness and complications in individuals with SCD. Topics researched included malaria, bacterial infections, vaccinations, dehydration, altitude, air travel, and travel preparedness. RESULTS: There is very little published literature that specifically addresses the risks faced by travelers with SCD. Rates of medical complications during travel appear to be high. There is a body of literature that describes complications of SCD in indigenous populations, particularly within Africa. The generalizability of these data to a traveler is uncertain. Combining these sources of data and the broader medical literature, we address major travel-related questions that may face a provider preparing an individual with SCD for safe travel. CONCLUSIONS: Travelers with SCD face considerable medical risks when traveling to developing tropical countries, including malaria, bacterial infections, hypovolemia, and sickle cell-associated vaso-occlusive crises. For individuals with SCD, frank counseling about the risks, vigilant preventative measures, and contingency planning for illness while abroad are necessary aspects of the pre-travel visit.

Full Text

Duke Authors

Cited Authors

  • Willen, SM; Thornburg, CD; Lantos, PM

Published Date

  • September 2014

Published In

Volume / Issue

  • 21 / 5

Start / End Page

  • 332 - 339

PubMed ID

  • 24947546

Pubmed Central ID

  • PMC4146746

Electronic International Standard Serial Number (EISSN)

  • 1708-8305

Digital Object Identifier (DOI)

  • 10.1111/jtm.12142


  • eng

Conference Location

  • England