Update on surgical therapies for intestinal failure.

Published

Journal Article (Review)

PURPOSE OF REVIEW: Parenteral nutrition enables long-term survival in patients with intestinal failure; however, it is associated with life-threatening complications necessitating alternative techniques of management to enable weaning parenteral nutrition and minimizing parenteral nutrition-associated comorbidities. This review aims at discussing the indications and techniques most commonly utilized for surgical management in a short gut. RECENT FINDINGS: Surgical therapy for short gut has evolved and undergone refinement in the past 30-40  years with the older procedures being largely abandoned and replaced by newer and refined techniques. Lengthening surgeries (longitudinal intestinal lengthening and tapering and serial transverse enteroplasty) are the most commonly applied procedures in a dilated bowel with intestinal transplantation option reserved as a last resort for recurrent life-threatening central venous line infections, progressive loss of central venous access, and development of progressive liver disease. SUMMARY: Management of intestinal failure requires a multidisciplinary approach to optimize intestinal rehabilitation and overall patient outcome. Although intestinal transplantation remains an excellent option for patients with severe life-threatening complications, autologous intestinal reconstruction appears to remain the better overall option.

Full Text

Duke Authors

Cited Authors

  • Sudan, D; Rege, A

Published Date

  • June 2014

Published In

Volume / Issue

  • 19 / 3

Start / End Page

  • 267 - 275

PubMed ID

  • 24752067

Pubmed Central ID

  • 24752067

Electronic International Standard Serial Number (EISSN)

  • 1531-7013

Digital Object Identifier (DOI)

  • 10.1097/MOT.0000000000000076

Language

  • eng

Conference Location

  • United States