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The complex role of DNA, histones and HMGB1 in the pathogenesis of SLE.

Publication ,  Journal Article
Pisetsky, DS
Published in: Autoimmunity
December 2014

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the production of antinuclear antibodies (ANA) in association with protean clinic manifestations. ANA can bind to nuclear molecules, most prominently DNA and histones in nucleosomes, to form complexes to promote pathogenesis. Because of the intrinsic immunological activity of the nuclear components, these complexes can amplify responses by interacting with diverse pattern recognition receptors and internal sensing systems. Among molecules associated with nucleosomal components, HMGB1, a non-histone protein, can emanate from activated and dying cells; HMGB1's immune activity is determined by post-translational modifications, redox state, and binding to other immune mediators. Although ANAs form complexes that deposit in the kidney or induce type 1 interferon, ANAs may also block immune activity. Together, these studies highlight the importance of complexes in the pathogenesis of lupus and their role as antigens, immunogens, and adjuvants.

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Published In

Autoimmunity

DOI

EISSN

1607-842X

Publication Date

December 2014

Volume

47

Issue

8

Start / End Page

487 / 493

Location

England

Related Subject Headings

  • Nucleosomes
  • Lupus Erythematosus, Systemic
  • Immunology
  • Humans
  • Histones
  • HMGB1 Protein
  • DNA
  • Autoimmunity
  • Antibodies, Antinuclear
  • Animals
 

Citation

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Chicago
ICMJE
MLA
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Pisetsky, D. S. (2014). The complex role of DNA, histones and HMGB1 in the pathogenesis of SLE. Autoimmunity, 47(8), 487–493. https://doi.org/10.3109/08916934.2014.921811
Pisetsky, David S. “The complex role of DNA, histones and HMGB1 in the pathogenesis of SLE.Autoimmunity 47, no. 8 (December 2014): 487–93. https://doi.org/10.3109/08916934.2014.921811.
Pisetsky DS. The complex role of DNA, histones and HMGB1 in the pathogenesis of SLE. Autoimmunity. 2014 Dec;47(8):487–93.
Pisetsky, David S. “The complex role of DNA, histones and HMGB1 in the pathogenesis of SLE.Autoimmunity, vol. 47, no. 8, Dec. 2014, pp. 487–93. Pubmed, doi:10.3109/08916934.2014.921811.
Pisetsky DS. The complex role of DNA, histones and HMGB1 in the pathogenesis of SLE. Autoimmunity. 2014 Dec;47(8):487–493.

Published In

Autoimmunity

DOI

EISSN

1607-842X

Publication Date

December 2014

Volume

47

Issue

8

Start / End Page

487 / 493

Location

England

Related Subject Headings

  • Nucleosomes
  • Lupus Erythematosus, Systemic
  • Immunology
  • Humans
  • Histones
  • HMGB1 Protein
  • DNA
  • Autoimmunity
  • Antibodies, Antinuclear
  • Animals