Skip to main content

Admission cell free DNA levels predict 28-day mortality in patients with severe sepsis in intensive care.

Publication ,  Journal Article
Avriel, A; Paryente Wiessman, M; Almog, Y; Perl, Y; Novack, V; Galante, O; Klein, M; Pencina, MJ; Douvdevani, A
Published in: PLoS One
2014

AIM: The aim of the current study is to assess the mortality prediction accuracy of circulating cell-free DNA (CFD) level at admission measured by a new simplified method. MATERIALS AND METHODS: CFD levels were measured by a direct fluorescence assay in severe sepsis patients on intensive care unit (ICU) admission. In-hospital and/or twenty eight day all-cause mortality was the primary outcome. RESULTS: Out of 108 patients with median APACHE II of 20, 32.4% have died in hospital/or at 28-day. CFD levels were higher in decedents: median 3469.0 vs. 1659 ng/ml, p<0.001. In multivariable model APACHE II score and CFD (quartiles) were significantly associated with the mortality: odds ratio of 1.05, p = 0.049 and 2.57, p<0.001 per quartile respectively. C-statistics for the models was 0.79 for CFD and 0.68 for APACHE II. Integrated discrimination improvement (IDI) analyses showed that CFD and CFD+APACHE II score models had better discriminatory ability than APACHE II score alone. CONCLUSIONS: CFD level assessed by a new, simple fluorometric-assay is an accurate predictor of acute mortality among ICU patients with severe sepsis. Comparison of CFD to APACHE II score and Procalcitonin (PCT), suggests that CFD has the potential to improve clinical decision making.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2014

Volume

9

Issue

6

Start / End Page

e100514

Location

United States

Related Subject Headings

  • Survival Rate
  • Sepsis
  • Prognosis
  • Middle Aged
  • Male
  • Humans
  • Hospital Mortality
  • General Science & Technology
  • Fluorometry
  • Fluorescence
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Avriel, A., Paryente Wiessman, M., Almog, Y., Perl, Y., Novack, V., Galante, O., … Douvdevani, A. (2014). Admission cell free DNA levels predict 28-day mortality in patients with severe sepsis in intensive care. PLoS One, 9(6), e100514. https://doi.org/10.1371/journal.pone.0100514
Avriel, Avital, Maya Paryente Wiessman, Yaniv Almog, Yael Perl, Victor Novack, Ori Galante, Moti Klein, Michael J. Pencina, and Amos Douvdevani. “Admission cell free DNA levels predict 28-day mortality in patients with severe sepsis in intensive care.PLoS One 9, no. 6 (2014): e100514. https://doi.org/10.1371/journal.pone.0100514.
Avriel A, Paryente Wiessman M, Almog Y, Perl Y, Novack V, Galante O, et al. Admission cell free DNA levels predict 28-day mortality in patients with severe sepsis in intensive care. PLoS One. 2014;9(6):e100514.
Avriel, Avital, et al. “Admission cell free DNA levels predict 28-day mortality in patients with severe sepsis in intensive care.PLoS One, vol. 9, no. 6, 2014, p. e100514. Pubmed, doi:10.1371/journal.pone.0100514.
Avriel A, Paryente Wiessman M, Almog Y, Perl Y, Novack V, Galante O, Klein M, Pencina MJ, Douvdevani A. Admission cell free DNA levels predict 28-day mortality in patients with severe sepsis in intensive care. PLoS One. 2014;9(6):e100514.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2014

Volume

9

Issue

6

Start / End Page

e100514

Location

United States

Related Subject Headings

  • Survival Rate
  • Sepsis
  • Prognosis
  • Middle Aged
  • Male
  • Humans
  • Hospital Mortality
  • General Science & Technology
  • Fluorometry
  • Fluorescence