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Effects of glucagon like peptide-1 to mediate glycemic effects of weight loss surgery.

Publication ,  Journal Article
Salehi, M; D'Alessio, DA
Published in: Rev Endocr Metab Disord
September 2014

To date, weight loss surgeries are the most effective treatment for obesity and glycemic control in patients with type 2 diabetes. Roux-en-Y gastric bypass surgery (RYGB) and sleeve gastrectomy (SG), two widely used bariatric procedures for the treatment of obesity, induce diabetes remission independent of weight loss while glucose improvement after adjustable gastric banding (AGB) is proportional to the amount of weight loss. The immediate, weight-loss independent glycemic effect of gastric bypass has been attributed to postprandial hyperinsulinemia and an enhanced incretin effect. The rapid passage of nutrients into the intestine likely accounts for significantly enhanced glucagon like-peptide 1 (GLP-1) secretion, and postprandial hyperinsulinemia after GB is typically attributed to the combined effects of elevated glucose and GLP-1. For this review we focus on the beneficial effects of the three most commonly performed bariatric procedures, RYGB, SG, and AGB, on glucose metabolism and diabetes remission. Central to this discussion will be the extent to which the effects of surgery are mediated by GLP-1. Better understanding of these mechanisms could provide insight to development of novel therapeutic strategies for treatment of diabetes as well as refinement of surgical techniques.

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Published In

Rev Endocr Metab Disord

DOI

EISSN

1573-2606

Publication Date

September 2014

Volume

15

Issue

3

Start / End Page

171 / 179

Location

Germany

Related Subject Headings

  • Weight Loss
  • Obesity
  • Male
  • Humans
  • Glucagon-Like Peptide 1
  • Female
  • Endocrinology & Metabolism
  • Diabetes Mellitus, Type 2
  • Blood Glucose
  • Bariatric Surgery
 

Citation

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Salehi, M., & D’Alessio, D. A. (2014). Effects of glucagon like peptide-1 to mediate glycemic effects of weight loss surgery. Rev Endocr Metab Disord, 15(3), 171–179. https://doi.org/10.1007/s11154-014-9291-y
Salehi, Marzieh, and David A. D’Alessio. “Effects of glucagon like peptide-1 to mediate glycemic effects of weight loss surgery.Rev Endocr Metab Disord 15, no. 3 (September 2014): 171–79. https://doi.org/10.1007/s11154-014-9291-y.
Salehi M, D’Alessio DA. Effects of glucagon like peptide-1 to mediate glycemic effects of weight loss surgery. Rev Endocr Metab Disord. 2014 Sep;15(3):171–9.
Salehi, Marzieh, and David A. D’Alessio. “Effects of glucagon like peptide-1 to mediate glycemic effects of weight loss surgery.Rev Endocr Metab Disord, vol. 15, no. 3, Sept. 2014, pp. 171–79. Pubmed, doi:10.1007/s11154-014-9291-y.
Salehi M, D’Alessio DA. Effects of glucagon like peptide-1 to mediate glycemic effects of weight loss surgery. Rev Endocr Metab Disord. 2014 Sep;15(3):171–179.
Journal cover image

Published In

Rev Endocr Metab Disord

DOI

EISSN

1573-2606

Publication Date

September 2014

Volume

15

Issue

3

Start / End Page

171 / 179

Location

Germany

Related Subject Headings

  • Weight Loss
  • Obesity
  • Male
  • Humans
  • Glucagon-Like Peptide 1
  • Female
  • Endocrinology & Metabolism
  • Diabetes Mellitus, Type 2
  • Blood Glucose
  • Bariatric Surgery