Null association between vitamin D and PSA levels among black men in a vitamin D supplementation trial.

Journal Article (Journal Article)


Black men exhibit a high prevalence of vitamin D deficiency as well as a higher incidence of prostate cancer and higher mortality rates from prostate cancer than Whites. There are few data about the effect of vitamin D3 (cholecalciferol) supplementation on prostate-specific antigen (PSA) in healthy Black men.


During three winters from 2007 to 2010, 105 Black men (median age, 48.9 years) of Boston, MA were randomized into a four-arm, double-blind trial for 3 months of placebo, 1,000, 2,000, or 4,000 U of vitamin D3. At baseline and 3 months, free and total PSA was measured.


With vitamin D supplementation, no significant differences in free and total PSA were observed; free PSA, -0.0004 ng/mL (P = 0.94) and total PSA, -0.004 ng/mL (P = 0.92) for each additional 1,000 U/d of vitamin D3.


Within an unselected population of healthy Black men without a cancer diagnosis, we found no effect of vitamin D supplementation on free or total PSA.


These findings support prior findings of no change in PSA with vitamin D supplementation and emphasize the need for new methods to assess the influence of vitamin D supplementation on prostate cancer prevention.

Full Text

Duke Authors

Cited Authors

  • Chandler, PD; Giovannucci, EL; Scott, JB; Bennett, GG; Ng, K; Chan, AT; Hollis, BW; Emmons, KM; Fuchs, CS; Drake, BF

Published Date

  • September 2014

Published In

Volume / Issue

  • 23 / 9

Start / End Page

  • 1944 - 1947

PubMed ID

  • 24974387

Pubmed Central ID

  • PMC4167903

Electronic International Standard Serial Number (EISSN)

  • 1538-7755

International Standard Serial Number (ISSN)

  • 1055-9965

Digital Object Identifier (DOI)

  • 10.1158/1055-9965.epi-14-0522


  • eng