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Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates.

Publication ,  Journal Article
Mueller, JK; Grigsby, EM; Prevosto, V; Petraglia, FW; Rao, H; Deng, Z-D; Peterchev, AV; Sommer, MA; Egner, T; Platt, ML; Grill, WM
Published in: Nat Neurosci
August 2014

Transcranial magnetic stimulation (TMS) is a widely used, noninvasive method for stimulating nervous tissue, yet its mechanisms of effect are poorly understood. Here we report new methods for studying the influence of TMS on single neurons in the brain of alert non-human primates. We designed a TMS coil that focuses its effect near the tip of a recording electrode and recording electronics that enable direct acquisition of neuronal signals at the site of peak stimulus strength minimally perturbed by stimulation artifact in awake monkeys (Macaca mulatta). We recorded action potentials within ∼1 ms after 0.4-ms TMS pulses and observed changes in activity that differed significantly for active stimulation as compared with sham stimulation. This methodology is compatible with standard equipment in primate laboratories, allowing easy implementation. Application of these tools will facilitate the refinement of next generation TMS devices, experiments and treatment protocols.

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Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

August 2014

Volume

17

Issue

8

Start / End Page

1130 / 1136

Location

United States

Related Subject Headings

  • Transcranial Magnetic Stimulation
  • Prefrontal Cortex
  • Patch-Clamp Techniques
  • Neurons
  • Neurology & Neurosurgery
  • Male
  • Macaca mulatta
  • Female
  • Equipment Design
  • Electrodes
 

Citation

APA
Chicago
ICMJE
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Mueller, J. K., Grigsby, E. M., Prevosto, V., Petraglia, F. W., Rao, H., Deng, Z.-D., … Grill, W. M. (2014). Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates. Nat Neurosci, 17(8), 1130–1136. https://doi.org/10.1038/nn.3751
Mueller, Jerel K., Erinn M. Grigsby, Vincent Prevosto, Frank W. Petraglia, Hrishikesh Rao, Zhi-De Deng, Angel V. Peterchev, et al. “Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates.Nat Neurosci 17, no. 8 (August 2014): 1130–36. https://doi.org/10.1038/nn.3751.
Mueller JK, Grigsby EM, Prevosto V, Petraglia FW, Rao H, Deng Z-D, et al. Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates. Nat Neurosci. 2014 Aug;17(8):1130–6.
Mueller, Jerel K., et al. “Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates.Nat Neurosci, vol. 17, no. 8, Aug. 2014, pp. 1130–36. Pubmed, doi:10.1038/nn.3751.
Mueller JK, Grigsby EM, Prevosto V, Petraglia FW, Rao H, Deng Z-D, Peterchev AV, Sommer MA, Egner T, Platt ML, Grill WM. Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates. Nat Neurosci. 2014 Aug;17(8):1130–1136.

Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

August 2014

Volume

17

Issue

8

Start / End Page

1130 / 1136

Location

United States

Related Subject Headings

  • Transcranial Magnetic Stimulation
  • Prefrontal Cortex
  • Patch-Clamp Techniques
  • Neurons
  • Neurology & Neurosurgery
  • Male
  • Macaca mulatta
  • Female
  • Equipment Design
  • Electrodes