Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates.

Journal Article

Transcranial magnetic stimulation (TMS) is a widely used, noninvasive method for stimulating nervous tissue, yet its mechanisms of effect are poorly understood. Here we report new methods for studying the influence of TMS on single neurons in the brain of alert non-human primates. We designed a TMS coil that focuses its effect near the tip of a recording electrode and recording electronics that enable direct acquisition of neuronal signals at the site of peak stimulus strength minimally perturbed by stimulation artifact in awake monkeys (Macaca mulatta). We recorded action potentials within ∼1 ms after 0.4-ms TMS pulses and observed changes in activity that differed significantly for active stimulation as compared with sham stimulation. This methodology is compatible with standard equipment in primate laboratories, allowing easy implementation. Application of these tools will facilitate the refinement of next generation TMS devices, experiments and treatment protocols.

Full Text

Duke Authors

Cited Authors

  • Mueller, JK; Grigsby, EM; Prevosto, V; Petraglia, FW; Rao, H; Deng, Z-D; Peterchev, AV; Sommer, MA; Egner, T; Platt, ML; Grill, WM

Published Date

  • August 2014

Published In

Volume / Issue

  • 17 / 8

Start / End Page

  • 1130 - 1136

PubMed ID

  • 24974797

Electronic International Standard Serial Number (EISSN)

  • 1546-1726

International Standard Serial Number (ISSN)

  • 1097-6256

Digital Object Identifier (DOI)

  • 10.1038/nn.3751

Language

  • eng