Eosinophil-associated lung diseases. A cry for surfactant proteins A and D help?

Journal Article (Journal Article;Review)

Surfactant proteins (SP)-A and SP-D (SP-A/-D) play important roles in numerous eosinophil-dominated diseases, including asthma, allergic bronchopulmonary aspergillosis, and allergic rhinitis. In these settings, SP-A/-D have been shown to modulate eosinophil chemotaxis, inhibit eosinophil mediator release, and mediate macrophage clearance of apoptotic eosinophils. Dysregulation of SP-A/-D function in eosinophil-dominated diseases is also not uncommon. Alterations in serum SP-A/-D levels are associated with disease severity in allergic rhinitis and chronic obstructive pulmonary disease. Furthermore, oligimerization of SP-A/-D, necessary for their proper function, can be perturbed by reactive nitrogen species, which are increased in eosinophilic disease. In this review, we highlight the associations of eosinophilic lung diseases with SP-A and SP-D levels and functions.

Full Text

Duke Authors

Cited Authors

  • Ledford, JG; Addison, KJ; Foster, MW; Que, LG

Published Date

  • November 2014

Published In

Volume / Issue

  • 51 / 5

Start / End Page

  • 604 - 614

PubMed ID

  • 24960334

Pubmed Central ID

  • PMC4224083

Electronic International Standard Serial Number (EISSN)

  • 1535-4989

Digital Object Identifier (DOI)

  • 10.1165/rcmb.2014-0095TR


  • eng

Conference Location

  • United States