The influence of oxidative stress on symptom occurrence, severity, and distress during childhood leukemia treatment.
Journal Article (Multicenter Study;Journal Article)
Purpose/objectivesTo explore the symptom trajectory during the first 16 months of childhood leukemia treatment and any associations with the oxidative stress pathway measured by cerebrospinal fluid (CSF) concentration of oxidized phosphatidylcholine (PC), the predominant glycerophospholipid in the brain and cell membranes.
DesignProspective, longitudinal design.
SettingTwo cancer centers in the southwestern United States.
Sample36 children (aged 3-14 years) newly diagnosed with acute lymphoblastic leukemia.
MethodsSymptoms were measured using the Memorial Symptom Assessment Scale at six specific time points during treatment. Biochemical changes in oxidative stress were measured by oxidized PC in the CSF.
Main research variablesChildhood cancer symptoms, oxidized PC.
FindingsSignificant differences were found in the number of symptoms experienced during the three phases of treatment. Symptom trajectory changes and influence of the oxidative stress pathway on symptom experiences were identified.
ConclusionsSymptoms experienced during treatment for childhood leukemia are associated with increased oxidative stress.
Implications for nursingChildren with leukemia experience symptoms throughout treatment. Physiologic measures indicate the influence of oxidative stress on symptoms.
- Hockenberry, MJ; Taylor, OA; Pasvogel, A; Rodgers, C; McCarthy, K; Gundy, P; Montgomery, DW; Ribbeck, P; Scheurer, ME; Moore, IMK
- July 2014
Volume / Issue
- 41 / 4
Start / End Page
- E238 - E247
Pubmed Central ID
Electronic International Standard Serial Number (EISSN)
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)