A review of the use of adjunctive therapies in severe acute asthma exacerbation in critically ill children.

Journal Article (Journal Article;Review)

Asthma is a common and potentially life threatening childhood condition. Asthma involves not only chronic airway remodeling, but may also include frequent exacerbations resulting from bronchospasm, edema, and mucus production. In children with severe exacerbations, standard therapy with β2-agonists, anti-cholinergic agents, oxygen, and systemic steroids may fail to reverse the severe airflow obstruction and necessitate use of adjunctive therapies. These therapies include intravenous or inhaled magnesium, inhaled helium-oxygen mixtures, intravenous methylxanthines, intravenous β2-agonists, and intravenous ketamine. Rarely, these measures are not successful and following the initiation of invasive mechanical ventilation, inhaled anesthetics or extracorporeal life support may be required. In this review, we discuss the mechanisms and evidence for adjunctive therapies in the setting of severe acute asthma exacerbations in children.

Full Text

Duke Authors

Cited Authors

  • Wong, JJM; Lee, JH; Turner, DA; Rehder, KJ

Published Date

  • August 2014

Published In

Volume / Issue

  • 8 / 4

Start / End Page

  • 423 - 441

PubMed ID

  • 24993063

Electronic International Standard Serial Number (EISSN)

  • 1747-6356

Digital Object Identifier (DOI)

  • 10.1586/17476348.2014.915752


  • eng

Conference Location

  • England