Sodium, potassium, and calcium are, in many respects, the cornerstones of neuronal signaling, but d-block metal ions also play important roles in brain function. The brain has unique needs for metalloenzymes that use iron, zinc, copper, and manganese, and in some cases the metal ions themselves have distinct roles. This chapter provides an overview of the movement, allocation, and uses of metal ions in various brain regions, cell types, and diseases, with emphasis on areas of particular interest to bioinorganic chemists, especially those areas where molecular details await to be uncovered. © 2013 Elsevier Ltd. All rights reserved.
Folk, DS; Kielar, F; Franz, KJ
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