Applications of RNA interference high-throughput screening technology in cancer biology and virology.
Journal Article (Journal Article;Review)
RNA interference (RNAi) is an ancient intra-cellular mechanism that regulates gene expression and cell function. Large-scale gene silencing using RNAi high-throughput screening (HTS) has opened an exciting frontier to systematically study gene function in mammalian cells. This approach enables researchers to identify gene function in a given biological context and will provide considerable novel insight. Here, we review RNAi HTS strategies and applications using case studies in cancer biology and virology.
Full Text
Duke Authors
Cited Authors
- Gao, S; Yang, C; Jiang, S; Xu, X-N; Lu, X; He, Y-W; Cheung, A; Wang, H
Published Date
- November 2014
Published In
Volume / Issue
- 5 / 11
Start / End Page
- 805 - 815
PubMed ID
- 24952721
Pubmed Central ID
- PMC4225462
Electronic International Standard Serial Number (EISSN)
- 1674-8018
Digital Object Identifier (DOI)
- 10.1007/s13238-014-0076-6
Language
- eng
Conference Location
- Germany