Applications of RNA interference high-throughput screening technology in cancer biology and virology.

Journal Article (Journal Article;Review)

RNA interference (RNAi) is an ancient intra-cellular mechanism that regulates gene expression and cell function. Large-scale gene silencing using RNAi high-throughput screening (HTS) has opened an exciting frontier to systematically study gene function in mammalian cells. This approach enables researchers to identify gene function in a given biological context and will provide considerable novel insight. Here, we review RNAi HTS strategies and applications using case studies in cancer biology and virology.

Full Text

Duke Authors

Cited Authors

  • Gao, S; Yang, C; Jiang, S; Xu, X-N; Lu, X; He, Y-W; Cheung, A; Wang, H

Published Date

  • November 2014

Published In

Volume / Issue

  • 5 / 11

Start / End Page

  • 805 - 815

PubMed ID

  • 24952721

Pubmed Central ID

  • PMC4225462

Electronic International Standard Serial Number (EISSN)

  • 1674-8018

Digital Object Identifier (DOI)

  • 10.1007/s13238-014-0076-6


  • eng

Conference Location

  • Germany