Kidney α-intercalated cells and lipocalin 2: defending the urinary tract.

Journal Article (Journal Article)

A growing body of evidence indicates that the kidneys contribute substantially to immune defense against pathogens in the urinary tract. In this issue, Paragas et al. report that α-intercalated cells (A-ICs) within the nephron collecting duct sense infecting Gram-negative bacteria, resulting in simultaneously secretion of the iron chelating protein lipocalin 2 (LCN2) and protons, which acidify the urine. A-IC-specific LCN2 and proton secretion markedly reduced the ability of infecting uropathogenic E. coli (UPEC) to grow and sustain infection. The capacity of A-ICs to sense and actively promote clearance of infecting bacteria in the lower urinary tract represents a novel function for these specialized kidney cells, which are best known for their role in modulating acid-base homeostasis.

Full Text

Duke Authors

Cited Authors

  • Miao, Y; Abraham, SN

Published Date

  • July 2014

Published In

Volume / Issue

  • 124 / 7

Start / End Page

  • 2844 - 2846

PubMed ID

  • 24937424

Pubmed Central ID

  • PMC4071399

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

Digital Object Identifier (DOI)

  • 10.1172/JCI76630


  • eng

Conference Location

  • United States