Speciation and decomposition pathways of ruthenium catalysts used for selective C-H hydroxylation


Journal Article

Mechanistic insight into a C-H hydroxylation reaction catalysed by [(Me3tacn)RuCl3] has been obtained using desorption electrospray ionization mass spectrometry (DESI-MS) to identify reactive intermediates and to determine the fate of the starting metal complex. Our studies provide direct evidence for the formation of a high-valent dioxo-Ru(vi) species, which is believed to be the active oxidant. Other unexpected Ru-oxo intermediates, however, have been identified and may also function as competent hydroxylating agents. Mass spectral data that substantiate putative mechanisms for catalyst arrest and highlight reactivity differences between [(Me 3tacn)RuCl3] and the corresponding tribromide adduct are also described. © the Partner Organisations 2014.

Full Text

Duke Authors

Cited Authors

  • Flender, C; Adams, AM; Roizen, JL; McNeill, E; Du Bois, J; Zare, RN

Published Date

  • January 1, 2014

Published In

Volume / Issue

  • 5 / 8

Start / End Page

  • 3309 - 3314

Electronic International Standard Serial Number (EISSN)

  • 2041-6539

International Standard Serial Number (ISSN)

  • 2041-6520

Digital Object Identifier (DOI)

  • 10.1039/c4sc01050g

Citation Source

  • Scopus