Scaling in neurotrauma: how do we apply animal experiments to people?

Journal Article (Journal Article)

Scaling is an essential component for translating the clinical outcomes of a neurotrauma model to the human equivalent. This article reviews the principles of biomechanical scaling for traumatic brain injuries, and a number of different approaches to scaling the dose (inputs) and response (outputs) of an animal model to humans are highlighted. A particular focus on blast injury scaling is given as an ongoing area of research, and discussion on the implications of scaling on the current blast TBI literature is provided. The risk of using neurotrauma models without considering an appropriate scaling method is that injuries may be induced with non-realistic loading conditions, and the injury mechanisms produced in the laboratory may not be consistent with those in the clinical setting.

Full Text

Duke Authors

Cited Authors

  • Panzer, MB; Wood, GW; Bass, CR

Published Date

  • November 2014

Published In

Volume / Issue

  • 261 /

Start / End Page

  • 120 - 126

PubMed ID

  • 25035134

Electronic International Standard Serial Number (EISSN)

  • 1090-2430

International Standard Serial Number (ISSN)

  • 0014-4886

Digital Object Identifier (DOI)

  • 10.1016/j.expneurol.2014.07.002

Language

  • eng