Will studies in individuals with systemic lupus erythematosus be the key to future HIV vaccine design?

Published

Journal Article

The induction of HIV-1 broadly neutralizing antibodies (bnAbs) remains the primary goal of a preventive HIV-1 vaccine but no HIV-1 vaccine candidate has succeeded in inducing bnAbs. All the bnAbs isolated from chronically HIV-1 infected subjects display one or more traits associated with control by host tolerance and immunoregulatory mechanisms, including reactivity against self antigens. Recent studies on a HIV-1 patient with concurrent systemic lupus erythematosus have informed on how similar bnAbs are to typical autoantibodies controlled by immune tolerance mechanisms. Future studies aimed at elucidating the intersection between autoantibodies generated in the context of systemic lupus erythematosus and the development of HIV-1 bnAbs will further our knowledge of specific roadblocks that hamper the production of bnAbs and, ultimately, inform us on how to implement vaccine strategies to circumvent them.

Full Text

Duke Authors

Cited Authors

  • Bonsignori, M

Published Date

  • November 2014

Published In

Volume / Issue

  • 13 / 11

Start / End Page

  • 1271 - 1273

PubMed ID

  • 25017952

Pubmed Central ID

  • 25017952

Electronic International Standard Serial Number (EISSN)

  • 1744-8395

International Standard Serial Number (ISSN)

  • 1476-0584

Digital Object Identifier (DOI)

  • 10.1586/14760584.2014.938056

Language

  • eng