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Detection of prostate cancer with multiparametric MRI (mpMRI): effect of dedicated reader education on accuracy and confidence of index and anterior cancer diagnosis.

Publication ,  Journal Article
Garcia-Reyes, K; Passoni, NM; Palmeri, ML; Kauffman, CR; Choudhury, KR; Polascik, TJ; Gupta, RT
Published in: Abdom Imaging
January 2015

PURPOSE: To evaluate the impact of dedicated reader education on accuracy/confidence of peripheral zone index cancer and anterior prostate cancer (PCa) diagnosis with mpMRI; secondary aim was to assess the ability of readers to differentiate low-grade cancer (Gleason 6 or below) from high-grade cancer (Gleason 7+). MATERIALS AND METHODS: Five blinded radiology fellows evaluated 31 total prostate mpMRIs in this IRB-approved, HIPAA-compliant, retrospective study for index lesion detection, confidence in lesion diagnosis (1-5 scale), and Gleason grade (Gleason 6 or lower vs. Gleason 7+). Following a dedicated education program, readers reinterpreted cases after a memory extinction period, blinded to initial reads. Reference standard was established combining whole mount histopathology with mpMRI findings by a board-certified radiologist with 5 years of prostate mpMRI experience. RESULTS: Index cancer detection: pre-education accuracy 74.2%; post-education accuracy 87.7% (p = 0.003). Confidence in index lesion diagnosis: pre-education 4.22 ± 1.04; post-education 3.75 ± 1.41 (p = 0.0004). Anterior PCa detection: pre-education accuracy 54.3%; post-education accuracy 94.3% (p = 0.001). Confidence in anterior PCa diagnosis: pre-education 3.22 ± 1.54; post-education 4.29 ± 0.83 (p = 0.0003). Gleason score accuracy: pre-education 54.8%; post-education 73.5% (p = 0.0005). CONCLUSIONS: A dedicated reader education program on PCa detection with mpMRI was associated with a statistically significant increase in diagnostic accuracy of index cancer and anterior cancer detection as well as Gleason grade identification as compared to pre-education values. This was also associated with a significant increase in reader diagnostic confidence. This suggests that substantial interobserver variability in mpMRI interpretation can potentially be reduced with a focus on education and that this can occur over a fellowship training year.

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Published In

Abdom Imaging

DOI

EISSN

1432-0509

Publication Date

January 2015

Volume

40

Issue

1

Start / End Page

134 / 142

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Reproducibility of Results
  • Prostatic Neoplasms
  • Prostate
  • Observer Variation
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Grading
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
 

Citation

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ICMJE
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Garcia-Reyes, K., Passoni, N. M., Palmeri, M. L., Kauffman, C. R., Choudhury, K. R., Polascik, T. J., & Gupta, R. T. (2015). Detection of prostate cancer with multiparametric MRI (mpMRI): effect of dedicated reader education on accuracy and confidence of index and anterior cancer diagnosis. Abdom Imaging, 40(1), 134–142. https://doi.org/10.1007/s00261-014-0197-7
Garcia-Reyes, Kirema, Niccolò M. Passoni, Mark L. Palmeri, Christopher R. Kauffman, Kingshuk Roy Choudhury, Thomas J. Polascik, and Rajan T. Gupta. “Detection of prostate cancer with multiparametric MRI (mpMRI): effect of dedicated reader education on accuracy and confidence of index and anterior cancer diagnosis.Abdom Imaging 40, no. 1 (January 2015): 134–42. https://doi.org/10.1007/s00261-014-0197-7.
Garcia-Reyes K, Passoni NM, Palmeri ML, Kauffman CR, Choudhury KR, Polascik TJ, et al. Detection of prostate cancer with multiparametric MRI (mpMRI): effect of dedicated reader education on accuracy and confidence of index and anterior cancer diagnosis. Abdom Imaging. 2015 Jan;40(1):134–42.
Garcia-Reyes, Kirema, et al. “Detection of prostate cancer with multiparametric MRI (mpMRI): effect of dedicated reader education on accuracy and confidence of index and anterior cancer diagnosis.Abdom Imaging, vol. 40, no. 1, Jan. 2015, pp. 134–42. Pubmed, doi:10.1007/s00261-014-0197-7.
Garcia-Reyes K, Passoni NM, Palmeri ML, Kauffman CR, Choudhury KR, Polascik TJ, Gupta RT. Detection of prostate cancer with multiparametric MRI (mpMRI): effect of dedicated reader education on accuracy and confidence of index and anterior cancer diagnosis. Abdom Imaging. 2015 Jan;40(1):134–142.

Published In

Abdom Imaging

DOI

EISSN

1432-0509

Publication Date

January 2015

Volume

40

Issue

1

Start / End Page

134 / 142

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Reproducibility of Results
  • Prostatic Neoplasms
  • Prostate
  • Observer Variation
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Grading
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging