Recent advances in the regulation of pancreatic secretion.

Journal Article (Journal Article;Review)

PURPOSE OF REVIEW: This review highlights recent progress made in the field of pancreatic secretion. RECENT FINDINGS: This review summarizes a number of recent studies demonstrating the intracellular pathways by which hormones and neural inputs regulate pancreatic exocrine and endocrine secretion. In particular, the effects of vasoactive intestinal peptide and secretin on intra-acinar cell adenosine 3',5'-cyclic monophosphate are explored. Considerable attention is paid to regulation of β-cell function and includes studies detailing the mechanisms of regulation of insulin by somatostatin, serotonin, and melanocortins. These studies emphasize the critical role that hormonal, paracrine, and neural factors play in glucose homeostasis. SUMMARY: Exocrine and endocrine pancreatic secretions are regulated by hormonal and neural mechanisms, and understanding these pathways will enable the discovery and design of new and improved therapies for prevention and control of diabetes and perhaps exocrine insufficiency.

Full Text

Duke Authors

Cited Authors

  • Chandra, R; Liddle, RA

Published Date

  • September 2014

Published In

Volume / Issue

  • 30 / 5

Start / End Page

  • 490 - 494

PubMed ID

  • 25003603

Pubmed Central ID

  • PMC4229368

Electronic International Standard Serial Number (EISSN)

  • 1531-7056

Digital Object Identifier (DOI)

  • 10.1097/MOG.0000000000000099


  • eng

Conference Location

  • United States