Skip to main content

Radiogenomic analysis of breast cancer: luminal B molecular subtype is associated with enhancement dynamics at MR imaging.

Publication ,  Journal Article
Mazurowski, MA; Zhang, J; Grimm, LJ; Yoon, SC; Silber, JI
Published in: Radiology
November 2014

PURPOSE: To investigate associations between breast cancer molecular subtype and semiautomatically extracted magnetic resonance (MR) imaging features. MATERIALS AND METHODS: Imaging and genomic data from the Cancer Genome Atlas and the Cancer Imaging Archive for 48 patients with breast cancer from four institutions in the United States were used in this institutional review board approval-exempt study. Computer vision algorithms were applied to extract 23 imaging features from lesions indicated by a breast radiologist on MR images. Morphologic, textural, and dynamic features were extracted. Molecular subtype was determined on the basis of genomic analysis. Associations between the imaging features and molecular subtype were evaluated by using logistic regression and likelihood ratio tests. The analysis controlled for the age of the patients, their menopausal status, and the orientation of the MR images (sagittal vs axial). RESULTS: There is an association (P = .0015) between the luminal B subtype and a dynamic contrast material-enhancement feature that quantifies the relationship between lesion enhancement and background parenchymal enhancement. Cancers with a higher ratio of lesion enhancement rate to background parenchymal enhancement rate are more likely to be luminal B subtype. CONCLUSION: The luminal B subtype of breast cancer is associated with MR imaging features that relate the enhancement dynamics of the tumor and the background parenchyma.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Radiology

DOI

EISSN

1527-1315

Publication Date

November 2014

Volume

273

Issue

2

Start / End Page

365 / 372

Location

United States

Related Subject Headings

  • Risk Assessment
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Magnetic Resonance Imaging
  • Humans
  • Genotype
  • Genomics
  • Genetic Predisposition to Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mazurowski, M. A., Zhang, J., Grimm, L. J., Yoon, S. C., & Silber, J. I. (2014). Radiogenomic analysis of breast cancer: luminal B molecular subtype is associated with enhancement dynamics at MR imaging. Radiology, 273(2), 365–372. https://doi.org/10.1148/radiol.14132641
Mazurowski, Maciej A., Jing Zhang, Lars J. Grimm, Sora C. Yoon, and James I. Silber. “Radiogenomic analysis of breast cancer: luminal B molecular subtype is associated with enhancement dynamics at MR imaging.Radiology 273, no. 2 (November 2014): 365–72. https://doi.org/10.1148/radiol.14132641.
Mazurowski MA, Zhang J, Grimm LJ, Yoon SC, Silber JI. Radiogenomic analysis of breast cancer: luminal B molecular subtype is associated with enhancement dynamics at MR imaging. Radiology. 2014 Nov;273(2):365–72.
Mazurowski, Maciej A., et al. “Radiogenomic analysis of breast cancer: luminal B molecular subtype is associated with enhancement dynamics at MR imaging.Radiology, vol. 273, no. 2, Nov. 2014, pp. 365–72. Pubmed, doi:10.1148/radiol.14132641.
Mazurowski MA, Zhang J, Grimm LJ, Yoon SC, Silber JI. Radiogenomic analysis of breast cancer: luminal B molecular subtype is associated with enhancement dynamics at MR imaging. Radiology. 2014 Nov;273(2):365–372.

Published In

Radiology

DOI

EISSN

1527-1315

Publication Date

November 2014

Volume

273

Issue

2

Start / End Page

365 / 372

Location

United States

Related Subject Headings

  • Risk Assessment
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Magnetic Resonance Imaging
  • Humans
  • Genotype
  • Genomics
  • Genetic Predisposition to Disease