Specification to biomineralization: following a single cell type as it constructs a skeleton.

Published

Journal Article

The sea urchin larva is shaped by a calcite endoskeleton. That skeleton is built by 64 primary mesenchyme cells (PMCs) in Lytechinus variegatus. The PMCs originate as micromeres due to an unequal fourth cleavage in the embryo. Micromeres are specified in a well-described molecular sequence and enter the blastocoel at a precise time using a classic epithelial-mesenchymal transition. To make the skeleton, the PMCs receive signaling inputs from the overlying ectoderm, which provides positional information as well as control of the growth of initial skeletal tri-radiates. The patterning of the skeleton is the result both of autonomous inputs from PMCs, including production of proteins that are included in the skeletal matrix, and of non-autonomous dynamic information from the ectoderm. Here, we summarize the wealth of information known about how a PMC contributes to the skeletal structure. The larval skeleton is a model for understanding how information encoded in DNA is translated into a three-dimensional crystalline structure.

Full Text

Duke Authors

Cited Authors

  • Lyons, DC; Martik, ML; Saunders, LR; McClay, DR

Published Date

  • October 2014

Published In

Volume / Issue

  • 54 / 4

Start / End Page

  • 723 - 733

PubMed ID

  • 25009306

Pubmed Central ID

  • 25009306

Electronic International Standard Serial Number (EISSN)

  • 1557-7023

International Standard Serial Number (ISSN)

  • 1540-7063

Digital Object Identifier (DOI)

  • 10.1093/icb/icu087

Language

  • eng