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Risk of positive nonsentinel nodes in women with 1-2 positive sentinel nodes related to age and molecular subtype approximated by receptor status.

Publication ,  Journal Article
Freedman, GM; Fowble, BL; Li, T; Hwang, ES; Schechter, N; Devarajan, K; Anderson, PR; Sigurdson, ER; Goldstein, LJ; Bleicher, RJ
Published in: Breast J
2014

We examine risk of positive nonsentinel axillary nodes (NSN) and ≥4 positive nodes in patients with 1-2 positive sentinel nodes (SN) by age and tumor subtype approximated by ER, PR, and Her2 receptor status. Review of two institutional databases demonstrated 284 women undergoing breast conservation between 1997 and 2008 for T1-2 tumors and 1 (229) or 2 (55) positive SN followed by completion dissection. The median number of SN and total axillary nodes removed were 2 (range 1-10) and 14 (range 6-37), respectively. The rate of positive NSNs (p = 0.5) or ≥4 positive nodes (p = 0.6) was not associated with age. NSN were positive in 36% of luminal A, 26% of luminal B, 21% of TN and 38% of Her2+ (p = 0.4). Four or more nodes were present in 17% of luminal A, 13% luminal of B, 0% of TN and 29% of Her2+ (p = 0.1). Microscopic extracapsular extension was significantly associated with having NSNs positive (55% versus 24%, p < 0.0001) and with having total ≥4 nodes positive (33% versus 7%, p < 0.0001). In a population that was largely eligible for ACOSOG Z0011, the risk of positive NSN or ≥4 positive nodes did not vary significantly by age. The TN subgroup had the lowest risk of both positive NSN or ≥4 positive nodes. Several high risk groups with >15% risk for having ≥4 positive nodes were identified. Further data is needed to confirm that ACOSOG Z0011 results are equally applicable to all molecular phenotypes.

Duke Scholars

Published In

Breast J

DOI

EISSN

1524-4741

Publication Date

2014

Volume

20

Issue

4

Start / End Page

358 / 363

Location

United States

Related Subject Headings

  • Triple Negative Breast Neoplasms
  • Sentinel Lymph Node Biopsy
  • Risk Factors
  • Receptors, Progesterone
  • Receptors, Estrogen
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Oncology & Carcinogenesis
  • Middle Aged
  • Lymphatic Metastasis
 

Citation

APA
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ICMJE
MLA
NLM
Freedman, G. M., Fowble, B. L., Li, T., Hwang, E. S., Schechter, N., Devarajan, K., … Bleicher, R. J. (2014). Risk of positive nonsentinel nodes in women with 1-2 positive sentinel nodes related to age and molecular subtype approximated by receptor status. Breast J, 20(4), 358–363. https://doi.org/10.1111/tbj.12276
Freedman, Gary M., Barbara L. Fowble, Tianyu Li, E Shelley Hwang, Naomi Schechter, Karthik Devarajan, Penny R. Anderson, Elin R. Sigurdson, Lori J. Goldstein, and Richard J. Bleicher. “Risk of positive nonsentinel nodes in women with 1-2 positive sentinel nodes related to age and molecular subtype approximated by receptor status.Breast J 20, no. 4 (2014): 358–63. https://doi.org/10.1111/tbj.12276.
Freedman GM, Fowble BL, Li T, Hwang ES, Schechter N, Devarajan K, et al. Risk of positive nonsentinel nodes in women with 1-2 positive sentinel nodes related to age and molecular subtype approximated by receptor status. Breast J. 2014;20(4):358–63.
Freedman, Gary M., et al. “Risk of positive nonsentinel nodes in women with 1-2 positive sentinel nodes related to age and molecular subtype approximated by receptor status.Breast J, vol. 20, no. 4, 2014, pp. 358–63. Pubmed, doi:10.1111/tbj.12276.
Freedman GM, Fowble BL, Li T, Hwang ES, Schechter N, Devarajan K, Anderson PR, Sigurdson ER, Goldstein LJ, Bleicher RJ. Risk of positive nonsentinel nodes in women with 1-2 positive sentinel nodes related to age and molecular subtype approximated by receptor status. Breast J. 2014;20(4):358–363.
Journal cover image

Published In

Breast J

DOI

EISSN

1524-4741

Publication Date

2014

Volume

20

Issue

4

Start / End Page

358 / 363

Location

United States

Related Subject Headings

  • Triple Negative Breast Neoplasms
  • Sentinel Lymph Node Biopsy
  • Risk Factors
  • Receptors, Progesterone
  • Receptors, Estrogen
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Oncology & Carcinogenesis
  • Middle Aged
  • Lymphatic Metastasis