Natural product synthesis at the interface of chemistry and biology.

Journal Article (Journal Article)

Nature has evolved to produce unique and diverse natural products that possess high target affinity and specificity. Natural products have been the richest sources for novel modulators of biomolecular function. Since the chemical synthesis of urea by Wöhler, organic chemists have been intrigued by natural products, leading to the evolution of the field of natural product synthesis over the past two centuries. Natural product synthesis has enabled natural products to play an essential role in drug discovery and chemical biology. With the introduction of novel, innovative concepts and strategies for synthetic efficiency, natural product synthesis in the 21st century is well poised to address the challenges and complexities faced by natural product chemistry and will remain essential to progress in biomedical sciences.

Full Text

Duke Authors

Cited Authors

  • Hong, J

Published Date

  • August 2014

Published In

Volume / Issue

  • 20 / 33

Start / End Page

  • 10204 - 10212

PubMed ID

  • 25043880

Pubmed Central ID

  • PMC4167019

Electronic International Standard Serial Number (EISSN)

  • 1521-3765

International Standard Serial Number (ISSN)

  • 0947-6539

Digital Object Identifier (DOI)

  • 10.1002/chem.201402804


  • eng