Optimization of magnetic switches for single particle and cell transport

Journal Article (Journal Article)

The ability to manipulate an ensemble of single particles and cells is a key aim of lab-on-a-chip research; however, the control mechanisms must be optimized for minimal power consumption to enable future large-scale implementation. Recently, we demonstrated a matter transport platform, which uses overlaid patterns of magnetic films and metallic current lines to control magnetic particles and magnetic-nanoparticle-labeled cells; however, we have made no prior attempts to optimize the device geometry and power consumption. Here, we provide an optimization analysis of particle-switching devices based on stochastic variation in the particle's size and magnetic content. These results are immediately applicable to the design of robust, multiplexed platforms capable of transporting, sorting, and storing single cells in large arrays with low power and high efficiency. © 2014 AIP Publishing LLC.

Full Text

Duke Authors

Cited Authors

  • Abedini-Nassab, R; Murdoch, DM; Kim, C; Yellen, BB

Published Date

  • June 28, 2014

Published In

Volume / Issue

  • 115 / 24

Electronic International Standard Serial Number (EISSN)

  • 1089-7550

International Standard Serial Number (ISSN)

  • 0021-8979

Digital Object Identifier (DOI)

  • 10.1063/1.4884609

Citation Source

  • Scopus