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The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes.

Publication ,  Journal Article
Greenbaum, L; Springer, RR; Lutz, MW; Heymann, A; Lubitz, I; Cooper, I; Kravitz, E; Sano, M; Roses, AD; Silverman, JM; Saunders, AM; Beeri, MS
Published in: Eur Neuropsychopharmacol
September 2014

The variable length poly-T, rs10524523 ('523') located within the TOMM40 gene, was recently associated with several phenotypes of cognitive function. The short (S) allele is associated with later AD onset age and better cognitive performance, compared to the longer alleles (long and very-long (VL)). There is strong linkage disequilibrium between variants in the TOMM40 and APOE genes. In this study, we investigated the effect of '523' on cognitive performance in a sample of cognitively normal Jewish elderly with type 2 diabetes, a group at particularly high risk for cognitive impairment. Using a MANCOVA procedure, we compared homozygous carriers of the S/S allele (N=179) to carriers of the VL/VL allele (N=152), controlling for demographic and cardiovascular covariates. The S/S group performed better than the VL/VL group (p=0.048), specifically in the executive function (p=0.04) and episodic memory (p=0.050) domains. These results suggest that previous findings of an association of the TOMM40 short allele with better cognitive performance, independently from the APOE variant status, are pertinent to elderly with diabetes.

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Published In

Eur Neuropsychopharmacol

DOI

EISSN

1873-7862

Publication Date

September 2014

Volume

24

Issue

9

Start / End Page

1492 / 1499

Location

Netherlands

Related Subject Headings

  • Psychiatry
  • Polymorphism, Single Nucleotide
  • Neuropsychological Tests
  • Mitochondrial Precursor Protein Import Complex Proteins
  • Membrane Transport Proteins
  • Male
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
  • Genetic Association Studies
 

Citation

APA
Chicago
ICMJE
MLA
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Greenbaum, L., Springer, R. R., Lutz, M. W., Heymann, A., Lubitz, I., Cooper, I., … Beeri, M. S. (2014). The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes. Eur Neuropsychopharmacol, 24(9), 1492–1499. https://doi.org/10.1016/j.euroneuro.2014.06.002
Greenbaum, Lior, Ramit Ravona Springer, Michael W. Lutz, Anthony Heymann, Irit Lubitz, Itzik Cooper, Efrat Kravitz, et al. “The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes.Eur Neuropsychopharmacol 24, no. 9 (September 2014): 1492–99. https://doi.org/10.1016/j.euroneuro.2014.06.002.
Greenbaum L, Springer RR, Lutz MW, Heymann A, Lubitz I, Cooper I, et al. The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes. Eur Neuropsychopharmacol. 2014 Sep;24(9):1492–9.
Greenbaum, Lior, et al. “The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes.Eur Neuropsychopharmacol, vol. 24, no. 9, Sept. 2014, pp. 1492–99. Pubmed, doi:10.1016/j.euroneuro.2014.06.002.
Greenbaum L, Springer RR, Lutz MW, Heymann A, Lubitz I, Cooper I, Kravitz E, Sano M, Roses AD, Silverman JM, Saunders AM, Beeri MS. The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes. Eur Neuropsychopharmacol. 2014 Sep;24(9):1492–1499.
Journal cover image

Published In

Eur Neuropsychopharmacol

DOI

EISSN

1873-7862

Publication Date

September 2014

Volume

24

Issue

9

Start / End Page

1492 / 1499

Location

Netherlands

Related Subject Headings

  • Psychiatry
  • Polymorphism, Single Nucleotide
  • Neuropsychological Tests
  • Mitochondrial Precursor Protein Import Complex Proteins
  • Membrane Transport Proteins
  • Male
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
  • Genetic Association Studies