α-Amination of Phosphonates: A Direct Synthesis of α-Amino Phosphonic Acids and Their Derivatives

Accepted

Journal Article

A direct approach to access important α-amino phosphonic acids and their derivatives through the formation of C-N bonds is described. Several α-amination reactions of phosphonates that involve electrophilic aminating agents are reviewed. A recent development is highlighted in which an acyclic or cyclic amine is introduced into the α-position of a phosphonate in one step through deprotonative formation of an α-zincate followed by copper-catalyzed amination with an O-acylhydroxylamine. © Georg Thieme Verlag.

Full Text

Duke Authors

Cited Authors

  • McDonald, SL; Wang, Q

Published Date

  • July 9, 2014

Published In

Electronic International Standard Serial Number (EISSN)

  • 1437-2096

International Standard Serial Number (ISSN)

  • 0936-5214

Digital Object Identifier (DOI)

  • 10.1055/s-0034-1378324

Citation Source

  • Scopus