Soluble P-selectin levels are associated with cardiovascular mortality and sudden cardiac death in male dialysis patients.

Published

Journal Article

BACKGROUND/AIMS: P-selectin is released by activated platelets and endothelium contributing to inflammation and thrombosis. We evaluated the association between soluble P-selectin and atherosclerotic cardiovascular disease (ASCVD) in dialysis patients. METHODS: We measured soluble P-selectin in serum from 824 incident dialysis patients. Using Cox proportional hazards models, we modeled the association of P-selectin levels with ASCVD events, cardiovascular mortality and sudden cardiac death. RESULTS: After adjustment for demographics, comorbidity and traditional cardiovascular risk factors, higher P-selectin levels were associated with increased risk of ASCVD and cardiovascular mortality among males (p = 0.02 and p = 0.01, respectively), but not females (p = 0.52 and p = 0.31, respectively; p interaction = 0.003), over a median of 38.2 months. Higher P-selectin was associated with a greater risk of sudden cardiac death among males (p = 0.05). The associations between increasing P-selectin and cardiovascular mortality as well as sudden cardiac death in males persisted after adjustment for C-reactive protein, interleukin-6, serum albumin and platelet count (p = 0.01 and p = 0.03, respectively). The risk for sudden cardiac death was more than 3 times greater for males in the highest tertile of soluble P-selectin compared with the lowest tertile after adjustment (HR: 3.19; 95% CI: 1.18 - 8.62; p = 0.02). CONCLUSION: P-selectin is associated with ASCVD, cardiovascular mortality and sudden cardiac death among male dialysis patients.

Full Text

Duke Authors

Cited Authors

  • Scialla, JJ; Plantinga, LC; Kao, WHL; Jaar, B; Powe, NR; Parekh, RS

Published Date

  • 2011

Published In

Volume / Issue

  • 33 / 3

Start / End Page

  • 224 - 230

PubMed ID

  • 21346329

Pubmed Central ID

  • 21346329

Electronic International Standard Serial Number (EISSN)

  • 1421-9670

Digital Object Identifier (DOI)

  • 10.1159/000324517

Language

  • eng

Conference Location

  • Switzerland