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Electrochemical biosensor of nanocube-augmented carbon nanotube networks.

Publication ,  Journal Article
Claussen, JC; Franklin, AD; Ul Haque, A; Porterfield, DM; Fisher, TS
Published in: ACS nano
January 2009

Networks of single-walled carbon nanotubes (SWCNTs) decorated with Au-coated Pd (Au/Pd) nanocubes are employed as electrochemical biosensors that exhibit excellent sensitivity (2.6 mA mM(-1) cm(-2)) and a low estimated detection limit (2.3 nM) at a signal-to-noise ratio of 3 (S/N = 3) in the amperometric sensing of hydrogen peroxide. Biofunctionalization of the Au/Pd nanocube-SWCNT biosensor is demonstrated with the selective immobilization of fluorescently labeled streptavidin on the nanocube surfaces via thiol linking. Similarly, glucose oxidase (GOx) is linked to the surface of the nanocubes for amperometric glucose sensing. The exhibited glucose detection limit of 1.3 muM (S/N = 3) and linear range spanning from 10 muM to 50 mM substantially surpass similar CNT-based biosensors. These results, combined with the structure's compatibility with a wide range of biofunctionalization procedures, would make the nanocube-SWCNT biosensor exceptionally useful for glucose detection in diabetic patients and well suited for a wide range of amperometric detection schemes for clinically important biomarkers.

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Published In

ACS nano

DOI

EISSN

1936-086X

ISSN

1936-0851

Publication Date

January 2009

Volume

3

Issue

1

Start / End Page

37 / 44

Related Subject Headings

  • Streptavidin
  • Palladium
  • Nanotubes, Carbon
  • Nanotechnology
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Models, Chemical
  • Metal Nanoparticles
  • Hydrogen Peroxide
  • Gold
 

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Claussen, J. C., Franklin, A. D., Ul Haque, A., Porterfield, D. M., & Fisher, T. S. (2009). Electrochemical biosensor of nanocube-augmented carbon nanotube networks. ACS Nano, 3(1), 37–44. https://doi.org/10.1021/nn800682m
Claussen, Jonathan C., Aaron D. Franklin, Aeraj Ul Haque, D Marshall Porterfield, and Timothy S. Fisher. “Electrochemical biosensor of nanocube-augmented carbon nanotube networks.ACS Nano 3, no. 1 (January 2009): 37–44. https://doi.org/10.1021/nn800682m.
Claussen JC, Franklin AD, Ul Haque A, Porterfield DM, Fisher TS. Electrochemical biosensor of nanocube-augmented carbon nanotube networks. ACS nano. 2009 Jan;3(1):37–44.
Claussen, Jonathan C., et al. “Electrochemical biosensor of nanocube-augmented carbon nanotube networks.ACS Nano, vol. 3, no. 1, Jan. 2009, pp. 37–44. Epmc, doi:10.1021/nn800682m.
Claussen JC, Franklin AD, Ul Haque A, Porterfield DM, Fisher TS. Electrochemical biosensor of nanocube-augmented carbon nanotube networks. ACS nano. 2009 Jan;3(1):37–44.
Journal cover image

Published In

ACS nano

DOI

EISSN

1936-086X

ISSN

1936-0851

Publication Date

January 2009

Volume

3

Issue

1

Start / End Page

37 / 44

Related Subject Headings

  • Streptavidin
  • Palladium
  • Nanotubes, Carbon
  • Nanotechnology
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Models, Chemical
  • Metal Nanoparticles
  • Hydrogen Peroxide
  • Gold