Chimerism in children with juvenile dermatomyositis.
Publication
, Journal Article
Reed, AM; Picornell, YJ; Harwood, A; Kredich, DW
Published in: Lancet
December 23, 2000
Juvenile dermatomyositis is a disease with similarities to chronic graft-versus-host disease. To identify whether chimerism is present in juvenile dermatomyositis, we investigated the families of 15 children with the disorder. Chimerism was identified by PCR in 13 of the 15 affected children, compared with five of 35 siblings (p<0.0001). Maternal cells among peripheral-blood mononuclear cells were detected in 11 of the 15 boys, compared with five of 17 unaffected controls (p=0.02), and in muscle tissue of 12 of 15 compared with two of ten unaffected siblings (p=0.005). These results suggest that chimerism may be involved in juvenile dermatomyositis.
Duke Scholars
Published In
Lancet
DOI
ISSN
0140-6736
Publication Date
December 23, 2000
Volume
356
Issue
9248
Start / End Page
2156 / 2157
Location
England
Related Subject Headings
- Pregnancy
- Maternal-Fetal Exchange
- Male
- Humans
- General & Internal Medicine
- Female
- Dermatomyositis
- Chimera
- Case-Control Studies
- 42 Health sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Reed, A. M., Picornell, Y. J., Harwood, A., & Kredich, D. W. (2000). Chimerism in children with juvenile dermatomyositis. Lancet, 356(9248), 2156–2157. https://doi.org/10.1016/S0140-6736(00)03500-5
Reed, A. M., Y. J. Picornell, A. Harwood, and D. W. Kredich. “Chimerism in children with juvenile dermatomyositis.” Lancet 356, no. 9248 (December 23, 2000): 2156–57. https://doi.org/10.1016/S0140-6736(00)03500-5.
Reed AM, Picornell YJ, Harwood A, Kredich DW. Chimerism in children with juvenile dermatomyositis. Lancet. 2000 Dec 23;356(9248):2156–7.
Reed, A. M., et al. “Chimerism in children with juvenile dermatomyositis.” Lancet, vol. 356, no. 9248, Dec. 2000, pp. 2156–57. Pubmed, doi:10.1016/S0140-6736(00)03500-5.
Reed AM, Picornell YJ, Harwood A, Kredich DW. Chimerism in children with juvenile dermatomyositis. Lancet. 2000 Dec 23;356(9248):2156–2157.
Published In
Lancet
DOI
ISSN
0140-6736
Publication Date
December 23, 2000
Volume
356
Issue
9248
Start / End Page
2156 / 2157
Location
England
Related Subject Headings
- Pregnancy
- Maternal-Fetal Exchange
- Male
- Humans
- General & Internal Medicine
- Female
- Dermatomyositis
- Chimera
- Case-Control Studies
- 42 Health sciences