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A prospective randomized wait list control trial of intravenous iron sucrose in older adults with unexplained anemia and serum ferritin 20-200 ng/mL.

Publication ,  Journal Article
Price, E; Artz, AS; Barnhart, H; Sapp, S; Chelune, G; Ershler, WB; Walston, JD; Gordeuk, VR; Berger, NA; Reuben, D; Prchal, J; Rao, SV ...
Published in: Blood Cells Mol Dis
December 2014

Anemia is common in older persons and is associated with substantial morbidity and mortality. One third of anemic older adults have unexplained anemia of the elderly (UAE). We carried out a randomized, wait list control trial in outpatients with UAE and serum ferritin levels between 20 and 200 ng/mL. Intravenous iron sucrose was given as a 200-mg weekly dose for 5 weeks either immediately after enrollment (immediate intervention group) or following a 12-week wait list period (wait list control group). The primary outcome measure was changed in 6-minute walk test (6MWT) distances from baseline to 12 weeks between the two groups. Hematologic, physical, cognitive, and quality of life parameters were also assessed. The study was terminated early after 19 subjects enrolled. The distance walked in the 6MWT increased a mean 8.05±55.48 m in the immediate intervention group and decreased a mean 11.45±49.46 m in the wait list control group (p=0.443). The hemoglobin increased a mean 0.39±0.46 g/dL in the immediate intervention group and declined a mean 0.39±0.85 g/dL in the wait list control group (p=0.026). Thus, a subgroup of adults with UAE may respond to intravenous iron. Enrollment of subjects into this type of study remains challenging.

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Published In

Blood Cells Mol Dis

DOI

EISSN

1096-0961

Publication Date

December 2014

Volume

53

Issue

4

Start / End Page

221 / 230

Location

United States

Related Subject Headings

  • Walking
  • Quality of Life
  • Psychological Tests
  • Male
  • Injections, Intravenous
  • Immunology
  • Humans
  • Glucaric Acid
  • Ferritins
  • Ferric Oxide, Saccharated
 

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Price, E., Artz, A. S., Barnhart, H., Sapp, S., Chelune, G., Ershler, W. B., … Cohen, H. J. (2014). A prospective randomized wait list control trial of intravenous iron sucrose in older adults with unexplained anemia and serum ferritin 20-200 ng/mL. Blood Cells Mol Dis, 53(4), 221–230. https://doi.org/10.1016/j.bcmd.2014.06.003
Price, Elizabeth, Andrew S. Artz, Huiman Barnhart, Shelly Sapp, Gordon Chelune, William B. Ershler, Jeremy D. Walston, et al. “A prospective randomized wait list control trial of intravenous iron sucrose in older adults with unexplained anemia and serum ferritin 20-200 ng/mL.Blood Cells Mol Dis 53, no. 4 (December 2014): 221–30. https://doi.org/10.1016/j.bcmd.2014.06.003.
Price E, Artz AS, Barnhart H, Sapp S, Chelune G, Ershler WB, et al. A prospective randomized wait list control trial of intravenous iron sucrose in older adults with unexplained anemia and serum ferritin 20-200 ng/mL. Blood Cells Mol Dis. 2014 Dec;53(4):221–30.
Price, Elizabeth, et al. “A prospective randomized wait list control trial of intravenous iron sucrose in older adults with unexplained anemia and serum ferritin 20-200 ng/mL.Blood Cells Mol Dis, vol. 53, no. 4, Dec. 2014, pp. 221–30. Pubmed, doi:10.1016/j.bcmd.2014.06.003.
Price E, Artz AS, Barnhart H, Sapp S, Chelune G, Ershler WB, Walston JD, Gordeuk VR, Berger NA, Reuben D, Prchal J, Rao SV, Roy CN, Supiano MA, Schrier SL, Cohen HJ. A prospective randomized wait list control trial of intravenous iron sucrose in older adults with unexplained anemia and serum ferritin 20-200 ng/mL. Blood Cells Mol Dis. 2014 Dec;53(4):221–230.
Journal cover image

Published In

Blood Cells Mol Dis

DOI

EISSN

1096-0961

Publication Date

December 2014

Volume

53

Issue

4

Start / End Page

221 / 230

Location

United States

Related Subject Headings

  • Walking
  • Quality of Life
  • Psychological Tests
  • Male
  • Injections, Intravenous
  • Immunology
  • Humans
  • Glucaric Acid
  • Ferritins
  • Ferric Oxide, Saccharated