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Incorporating biomarkers into cancer and aging research.

Publication ,  Journal Article
Hubbard, JM; Cohen, HJ; Muss, HB
Published in: J Clin Oncol
August 20, 2014

The challenge in treating the older adult with cancer is accurately accounting for and adapting management to the heterogeneity in health status of the individual patient. Many oncologists recognize that chronological age alone should not be the determinant when deciding on a treatment regimen. Easily measurable markers that provide an assessment of functional age would be ideal to assess frailty, which may predispose the patient to complications from cancer treatment, including increased toxicity, functional decline, decreased quality of life, and poorer survival. Several categories of potential markers, including chronic inflammatory markers, markers of cellular senescence, and imaging to assess muscle mass to detect sarcopenia, may provide insight into the likelihood of treatment-related complications. This article discusses candidate markers and strategies to evaluate these markers in cancer treatment trials, with the aim of developing a method to assess risk of oncologic outcomes and guide management decisions for both the physician and patient.

Duke Scholars

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

August 20, 2014

Volume

32

Issue

24

Start / End Page

2611 / 2616

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Geriatrics
  • Biomarkers, Tumor
  • Aging
  • Age Factors
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences
 

Citation

APA
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ICMJE
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Hubbard, J. M., Cohen, H. J., & Muss, H. B. (2014). Incorporating biomarkers into cancer and aging research. J Clin Oncol, 32(24), 2611–2616. https://doi.org/10.1200/JCO.2014.55.4261
Hubbard, Joleen M., Harvey J. Cohen, and Hyman B. Muss. “Incorporating biomarkers into cancer and aging research.J Clin Oncol 32, no. 24 (August 20, 2014): 2611–16. https://doi.org/10.1200/JCO.2014.55.4261.
Hubbard JM, Cohen HJ, Muss HB. Incorporating biomarkers into cancer and aging research. J Clin Oncol. 2014 Aug 20;32(24):2611–6.
Hubbard, Joleen M., et al. “Incorporating biomarkers into cancer and aging research.J Clin Oncol, vol. 32, no. 24, Aug. 2014, pp. 2611–16. Pubmed, doi:10.1200/JCO.2014.55.4261.
Hubbard JM, Cohen HJ, Muss HB. Incorporating biomarkers into cancer and aging research. J Clin Oncol. 2014 Aug 20;32(24):2611–2616.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

August 20, 2014

Volume

32

Issue

24

Start / End Page

2611 / 2616

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Geriatrics
  • Biomarkers, Tumor
  • Aging
  • Age Factors
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences