Prefrontal cortex reactivity underlies trait vulnerability to chronic social defeat stress.

Journal Article (Journal Article)

Psychological stress contributes to the onset and exacerbation of nearly all neuropsychiatric disorders. Individual differences in stress-regulatory circuits can therefore dramatically affect vulnerability to these illnesses. Here we identify neural circuit mechanisms underlying individual differences in vulnerability to stress using a murine model of chronic social defeat stress. In chronically stressed mice, we find that the degree of prefrontal cortex (PFC) control of amygdala activity predicts stress susceptibility in individual mice. Critically, we also find that individual differences in PFC activation (that is, reactivity) during exposure to an aggressor mouse predict the emergence stress-induced behavioural deficits in stress-naïve mice. Finally, we show that naturally occurring differences in PFC reactivity directly correspond to the intrinsic firing rate of PFC neurons. This demonstrates that naturally occurring differences in PFC function underlie individual differences in vulnerability to stress, raising the hypothesis that PFC modulation may prevent stress-induced psychiatric disorders.

Full Text

Duke Authors

Cited Authors

  • Kumar, S; Hultman, R; Hughes, D; Michel, N; Katz, BM; Dzirasa, K

Published Date

  • July 29, 2014

Published In

Volume / Issue

  • 5 /

Start / End Page

  • 4537 -

PubMed ID

  • 25072279

Pubmed Central ID

  • PMC4148151

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/ncomms5537


  • eng

Conference Location

  • England