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A comparison of neuropsychological performance between US and Russia: preparing for a global clinical trial.

Publication ,  Journal Article
Hayden, KM; Makeeva, OA; Newby, LK; Plassman, BL; Markova, VV; Dunham, A; Romero, HR; Melikyan, ZA; Germain, CM; Welsh-Bohmer, KA; Roses, AD ...
Published in: Alzheimers Dement
November 2014

BACKGROUND: Understanding regional differences in cognitive performance is important for interpretation of data from large multinational clinical trials. METHODS: Data from Durham and Cabarrus Counties in North Carolina, USA and Tomsk, Russia (n = 2972) were evaluated. The Montreal Cognitive Assessment (MoCA), Trail Making Test Part B (Trails B), Consortium to Establish a Registry for Alzheimer's Disease Word List Memory Test (WLM) delayed recall, and self-report Alzheimer's Disease Cooperative Studies Mail-In Cognitive Function Screening Instrument (MCFSI) were administered at each site. Multilevel modeling measured the variance explained by site and predictors of cognitive performance. RESULTS: Site differences accounted for 11% of the variation in the MoCA, 1.6% in Trails B, 1.7% in WLM, and 0.8% in MCFSI scores. Prior memory testing was significantly associated with WLM. Diabetes and stroke were significantly associated with Trails B and MCFSI. CONCLUSIONS: Sources of variation include cultural differences, health conditions, and exposure to test stimuli. Findings highlight the importance of local norms to interpret test performance.

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Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

November 2014

Volume

10

Issue

6

Start / End Page

760 / 768.e1

Location

United States

Related Subject Headings

  • United States
  • Translations
  • Surveys and Questionnaires
  • Russia
  • Neuropsychological Tests
  • Middle Aged
  • Male
  • Humans
  • Geriatrics
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Hayden, K. M., Makeeva, O. A., Newby, L. K., Plassman, B. L., Markova, V. V., Dunham, A., … TOMSK-DUKE Study Group Investigators, . (2014). A comparison of neuropsychological performance between US and Russia: preparing for a global clinical trial. Alzheimers Dement, 10(6), 760-768.e1. https://doi.org/10.1016/j.jalz.2014.02.008
Hayden, Kathleen M., Oksana A. Makeeva, L Kristin Newby, Brenda L. Plassman, Valentina V. Markova, Ashley Dunham, Heather R. Romero, et al. “A comparison of neuropsychological performance between US and Russia: preparing for a global clinical trial.Alzheimers Dement 10, no. 6 (November 2014): 760-768.e1. https://doi.org/10.1016/j.jalz.2014.02.008.
Hayden KM, Makeeva OA, Newby LK, Plassman BL, Markova VV, Dunham A, et al. A comparison of neuropsychological performance between US and Russia: preparing for a global clinical trial. Alzheimers Dement. 2014 Nov;10(6):760-768.e1.
Hayden, Kathleen M., et al. “A comparison of neuropsychological performance between US and Russia: preparing for a global clinical trial.Alzheimers Dement, vol. 10, no. 6, Nov. 2014, pp. 760-768.e1. Pubmed, doi:10.1016/j.jalz.2014.02.008.
Hayden KM, Makeeva OA, Newby LK, Plassman BL, Markova VV, Dunham A, Romero HR, Melikyan ZA, Germain CM, Welsh-Bohmer KA, Roses AD, TOMSK-DUKE Study Group Investigators. A comparison of neuropsychological performance between US and Russia: preparing for a global clinical trial. Alzheimers Dement. 2014 Nov;10(6):760-768.e1.
Journal cover image

Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

November 2014

Volume

10

Issue

6

Start / End Page

760 / 768.e1

Location

United States

Related Subject Headings

  • United States
  • Translations
  • Surveys and Questionnaires
  • Russia
  • Neuropsychological Tests
  • Middle Aged
  • Male
  • Humans
  • Geriatrics
  • Female