Understanding the mechanisms of action of antiangiogenic agents in metastatic colorectal cancer: a clinician's perspective.

Journal Article (Journal Article;Review)

Multiple clinical trials using bevacizumab, ziv-aflibercept, and regorafenib have recently demonstrated efficacy for patients with metastatic colorectal cancer. While the net clinical benefit of each of these therapies in the second-line and refractory disease setting appears to be similar, important distinctions exist between the agents at the pharmacodynamic, tumor microenvironment, and clinical levels. The purpose of this review is to survey the preclinical evidence regarding the mechanisms of action of these novel antiangiogenic agents and provide an overview of their respective clinical activity, while highlighting distinctions between therapies. Fundamental understanding of these distinctions may aid in clinical decisions and choice of antiangiogenic therapies.

Full Text

Duke Authors

Cited Authors

  • Clarke, JM; Hurwitz, HI; Rangwala, F

Published Date

  • October 2014

Published In

Volume / Issue

  • 40 / 9

Start / End Page

  • 1065 - 1072

PubMed ID

  • 25047778

Electronic International Standard Serial Number (EISSN)

  • 1532-1967

Digital Object Identifier (DOI)

  • 10.1016/j.ctrv.2014.07.001


  • eng

Conference Location

  • Netherlands