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Evaluation of the spectra Optia® mononuclear cell collection procedure in multiple myeloma patients.

Publication ,  Journal Article
Long, G; Waller, EK; Gregurek, S; Tricot, G; Marschner, S; Bill, J
Published in: J Clin Apher
February 2015

BACKGROUND: Peripheral blood stem cell (PBSC) rescue following myeloablative therapy is a mainstay of cancer therapy. To evaluate the ability of the Spectra Optia Apheresis System (SO), a newly developed apheresis device, the device was studied in multiple myeloma patients undergoing a first autologous PBSC transplant. AIM: To demonstrate that neutrophil recovery was not inferior to historical controls when SO harvested PBSCs were reinfused following myeloablative therapy. METHODS: Multiple myeloma patients were mobilized according to the standard practice at four clinical sites. Following mobilization, MNC collections were performed on the SO. The collected cells were cryopreserved and reinfused following myeloablative chemotherapy. Neutrophil recovery defined by an absolute neutrophil count exceeding 500/μL (ANC500) was compared to historical data for patients transplanted following apheresis using the COBE Spectra (CS) device. RESULTS: The median day to neutrophil recovery was 12 days (range 10-14 days), with no significant difference in engraftment comparing patients transplanted with stem cells collected using the SO versus historical cohort of patients collected with the CS. CD34+ cell and MNC collection efficiency (CE) were 69.3% and 65.0% for the SO and CS, respectively. Platelet CE, product hematocrit and product granulocytes (as % of WBCs) using the SO were 21%, 2.3% and 28%, respectively. There were no device-related severe adverse events. CONCLUSIONS: The study's results confirm that the Spectra Optia Apheresis System's MNC Collection Protocol is safe and effective for its intended use and that engraftment kinetics of cells collected by SO is not inferior to the CS System.

Duke Scholars

Published In

J Clin Apher

DOI

EISSN

1098-1101

Publication Date

February 2015

Volume

30

Issue

1

Start / End Page

1 / 7

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Autologous
  • Peripheral Blood Stem Cell Transplantation
  • Patient Safety
  • Neutrophils
  • Myeloablative Agonists
  • Multiple Myeloma
  • Middle Aged
  • Male
  • Leukocytes, Mononuclear
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Long, G., Waller, E. K., Gregurek, S., Tricot, G., Marschner, S., & Bill, J. (2015). Evaluation of the spectra Optia® mononuclear cell collection procedure in multiple myeloma patients. J Clin Apher, 30(1), 1–7. https://doi.org/10.1002/jca.21341
Long, Gwynn, Edmund K. Waller, Steven Gregurek, Guido Tricot, Susanne Marschner, and Jerry Bill. “Evaluation of the spectra Optia® mononuclear cell collection procedure in multiple myeloma patients.J Clin Apher 30, no. 1 (February 2015): 1–7. https://doi.org/10.1002/jca.21341.
Long G, Waller EK, Gregurek S, Tricot G, Marschner S, Bill J. Evaluation of the spectra Optia® mononuclear cell collection procedure in multiple myeloma patients. J Clin Apher. 2015 Feb;30(1):1–7.
Long, Gwynn, et al. “Evaluation of the spectra Optia® mononuclear cell collection procedure in multiple myeloma patients.J Clin Apher, vol. 30, no. 1, Feb. 2015, pp. 1–7. Pubmed, doi:10.1002/jca.21341.
Long G, Waller EK, Gregurek S, Tricot G, Marschner S, Bill J. Evaluation of the spectra Optia® mononuclear cell collection procedure in multiple myeloma patients. J Clin Apher. 2015 Feb;30(1):1–7.
Journal cover image

Published In

J Clin Apher

DOI

EISSN

1098-1101

Publication Date

February 2015

Volume

30

Issue

1

Start / End Page

1 / 7

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Autologous
  • Peripheral Blood Stem Cell Transplantation
  • Patient Safety
  • Neutrophils
  • Myeloablative Agonists
  • Multiple Myeloma
  • Middle Aged
  • Male
  • Leukocytes, Mononuclear