Emerging targets in neuroinflammation-driven chronic pain.

Journal Article (Journal Article;Review)

Current analgesics predominately modulate pain transduction and transmission in neurons and have limited success in controlling disease progression. Accumulating evidence suggests that neuroinflammation, which is characterized by infiltration of immune cells, activation of glial cells and production of inflammatory mediators in the peripheral and central nervous system, has an important role in the induction and maintenance of chronic pain. This Review focuses on emerging targets - such as chemokines, proteases and the WNT pathway - that promote spinal cord neuroinflammation and chronic pain. It also highlights the anti-inflammatory and pro-resolution lipid mediators that act on immune cells, glial cells and neurons to resolve neuroinflammation, synaptic plasticity and pain. Targeting excessive neuroinflammation could offer new therapeutic opportunities for chronic pain and related neurological and psychiatric disorders.

Full Text

Duke Authors

Cited Authors

  • Ji, R-R; Xu, Z-Z; Gao, Y-J

Published Date

  • July 2014

Published In

Volume / Issue

  • 13 / 7

Start / End Page

  • 533 - 548

PubMed ID

  • 24948120

Pubmed Central ID

  • PMC4228377

Electronic International Standard Serial Number (EISSN)

  • 1474-1784

Digital Object Identifier (DOI)

  • 10.1038/nrd4334


  • eng

Conference Location

  • England