Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.

Published

Journal Article

We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.

Full Text

Duke Authors

Cited Authors

  • Wolpin, BM; Rizzato, C; Kraft, P; Kooperberg, C; Petersen, GM; Wang, Z; Arslan, AA; Beane-Freeman, L; Bracci, PM; Buring, J; Canzian, F; Duell, EJ; Gallinger, S; Giles, GG; Goodman, GE; Goodman, PJ; Jacobs, EJ; Kamineni, A; Klein, AP; Kolonel, LN; Kulke, MH; Li, D; Malats, N; Olson, SH; Risch, HA; Sesso, HD; Visvanathan, K; White, E; Zheng, W; Abnet, CC; Albanes, D; Andreotti, G; Austin, MA; Barfield, R; Basso, D; Berndt, SI; Boutron-Ruault, M-C; Brotzman, M; Büchler, MW; Bueno-de-Mesquita, HB; Bugert, P; Burdette, L; Campa, D; Caporaso, NE; Capurso, G; Chung, C; Cotterchio, M; Costello, E; Elena, J; Funel, N; Gaziano, JM; Giese, NA; Giovannucci, EL; Goggins, M; Gorman, MJ; Gross, M; Haiman, CA; Hassan, M; Helzlsouer, KJ; Henderson, BE; Holly, EA; Hu, N; Hunter, DJ; Innocenti, F; Jenab, M; Kaaks, R; Key, TJ; Khaw, K-T; Klein, EA; Kogevinas, M; Krogh, V; Kupcinskas, J; Kurtz, RC; LaCroix, A; Landi, MT; Landi, S; Le Marchand, L; Mambrini, A; Mannisto, S; Milne, RL; Nakamura, Y; Oberg, AL; Owzar, K; Patel, AV; Peeters, PHM; Peters, U; Pezzilli, R; Piepoli, A; Porta, M; Real, FX; Riboli, E; Rothman, N; Scarpa, A; Shu, X-O; Silverman, DT; Soucek, P; Sund, M; Talar-Wojnarowska, R; Taylor, PR; Theodoropoulos, GE; Thornquist, M; Tjønneland, A; Tobias, GS; Trichopoulos, D; Vodicka, P; Wactawski-Wende, J; Wentzensen, N; Wu, C; Yu, H; Yu, K; Zeleniuch-Jacquotte, A; Hoover, R; Hartge, P; Fuchs, C; Chanock, SJ; Stolzenberg-Solomon, RS; Amundadottir, LT

Published Date

  • September 2014

Published In

Volume / Issue

  • 46 / 9

Start / End Page

  • 994 - 1000

PubMed ID

  • 25086665

Pubmed Central ID

  • 25086665

Electronic International Standard Serial Number (EISSN)

  • 1546-1718

Digital Object Identifier (DOI)

  • 10.1038/ng.3052

Language

  • eng

Conference Location

  • United States