Diabetes and cardiovascular disease in older adults: current status and future directions.

Published

Journal Article

The prevalence of diabetes increases with age, driven in part by an absolute increase in incidence among adults aged 65 years and older. Individuals with diabetes are at higher risk for cardiovascular disease, and age strongly predicts cardiovascular complications. Inflammation and oxidative stress appear to play some role in the mechanisms underlying aging, diabetes, cardiovascular disease, and other complications of diabetes. However, the mechanisms underlying the age-associated increase in risk for diabetes and diabetes-related cardiovascular disease remain poorly understood. Moreover, because of the heterogeneity of the older population, a lack of understanding of the biology of aging, and inadequate study of the effects of treatments on traditional complications and geriatric conditions associated with diabetes, no consensus exists on the optimal interventions for older diabetic adults. The Association of Specialty Professors, along with the National Institute on Aging, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Heart, Lung, and Blood Institute, and the American Diabetes Association, held a workshop, summarized in this Perspective, to discuss current knowledge regarding diabetes and cardiovascular disease in older adults, identify gaps, and propose questions to guide future research.

Full Text

Duke Authors

Cited Authors

  • Halter, JB; Musi, N; McFarland Horne, F; Crandall, JP; Goldberg, A; Harkless, L; Hazzard, WR; Huang, ES; Kirkman, MS; Plutzky, J; Schmader, KE; Zieman, S; High, KP

Published Date

  • August 2014

Published In

Volume / Issue

  • 63 / 8

Start / End Page

  • 2578 - 2589

PubMed ID

  • 25060886

Pubmed Central ID

  • 25060886

Electronic International Standard Serial Number (EISSN)

  • 1939-327X

International Standard Serial Number (ISSN)

  • 0012-1797

Digital Object Identifier (DOI)

  • 10.2337/db14-0020

Language

  • eng