OMERACT endorsement of measures of outcome for studies of acute gout.

Journal Article (Journal Article)

OBJECTIVE: To determine the extent to which participants at the Outcome Measures in Rheumatology (OMERACT) 11 meeting agree that instruments used in clinical trials to measure OMERACT core outcome domains in acute gout fulfill OMERACT filter requirements of truth, discrimination, and feasibility; and where future research efforts need to be directed. METHODS: Results of a systematic literature review and analysis of individual-level data from recent clinical studies of acute gout were presented to OMERACT participants. The information was discussed in breakout groups, and opinion was defined by subsequent voting in a plenary session. Endorsement was defined as at least 70% of participants voting in agreement with the proposition (where the denominator excluded those participants who did not vote or who voted "don't know"). RESULTS: The following measures were endorsed for use in clinical trials of acute gout: (1) 5-point Likert scale and/or visual analog scale (0 to 100 mm) to measure pain; (2) 4-point Likert scale for joint swelling; (3) 4-point Likert scale for joint tenderness; and (4) 5-point Likert scale for patient global assessment of response to treatment. Measures for the activity limitations domain were not endorsed. CONCLUSION: Measures of pain, joint swelling, joint tenderness, and patient global assessment in acute gout were endorsed at OMERACT 11. These measures should now be used in clinical trials of acute gout.

Full Text

Duke Authors

Cited Authors

  • Singh, JA; Taylor, WJ; Dalbeth, N; Simon, LS; Sundy, J; Grainger, R; Alten, R; March, L; Strand, V; Wells, G; Khanna, D; McQueen, F; Schlesinger, N; Boonen, A; Boers, M; Saag, KG; Schumacher, HR; Edwards, NL

Published Date

  • March 2014

Published In

Volume / Issue

  • 41 / 3

Start / End Page

  • 569 - 573

PubMed ID

  • 24334651

Pubmed Central ID

  • 24334651

International Standard Serial Number (ISSN)

  • 0315-162X

Digital Object Identifier (DOI)

  • 10.3899/jrheum.131246


  • eng

Conference Location

  • Canada