Weight changes in obese adults 6-months after discontinuation of double-blind zonisamide or placebo treatment
We evaluated weight changes in obese patients at 6-months after they ended participation in a 12-month randomised controlled trial in which they received daily placebo, zonisamide 200mg or zonisamide 400mg, in addition to lifestyle counselling. Of the originally randomised 225 patients, 218 completed month-12 when study interventions were discontinued. For the 154 patients who returned for 6-month follow-up off-treatment, weight changes between month-12 and month-18 for placebo (n=53), zonisamide 200mg (n=49) and zonisamide 400mg groups (n=52) were 0.5kg [95% confidence interval (CI), -0.8 to 1.8; 0.7%], 1.5kg (0.2-2.8; 1.6%; p=0.26 vs. placebo) and 2.4kg (1.1-3.7; 2.6%; p=0.04 vs. placebo), respectively. Our results suggest that although zonisamide 400mg daily for 12-months resulted in greater weight loss than with placebo, weight regain after discontinuation of interventions was greater in the zonisamide 400mg group than placebo group. © 2014 John Wiley & Sons Ltd.
Shin, JH; Gadde, KM; Østbye, T; Bray, GA
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