Beyond genotype: serotonin transporter epigenetic modification predicts human brain function.
Journal Article (Journal Article)
We examined epigenetic regulation in regards to behaviorally and clinically relevant human brain function. Specifically, we found that increased promoter methylation of the serotonin transporter gene predicted increased threat-related amygdala reactivity and decreased mRNA expression in postmortem amygdala tissue. These patterns were independent of functional genetic variation in the same region. Furthermore, the association with amygdala reactivity was replicated in a second cohort and was robust to both sampling methods and age.
- Nikolova, YS; Koenen, KC; Galea, S; Wang, C-M; Seney, ML; Sibille, E; Williamson, DE; Hariri, AR
- September 2014
Volume / Issue
- 17 / 9
Start / End Page
- 1153 - 1155
Pubmed Central ID
Electronic International Standard Serial Number (EISSN)
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)