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Beyond genotype: serotonin transporter epigenetic modification predicts human brain function.

Publication ,  Journal Article
Nikolova, YS; Koenen, KC; Galea, S; Wang, C-M; Seney, ML; Sibille, E; Williamson, DE; Hariri, AR
Published in: Nature neuroscience
September 2014

We examined epigenetic regulation in regards to behaviorally and clinically relevant human brain function. Specifically, we found that increased promoter methylation of the serotonin transporter gene predicted increased threat-related amygdala reactivity and decreased mRNA expression in postmortem amygdala tissue. These patterns were independent of functional genetic variation in the same region. Furthermore, the association with amygdala reactivity was replicated in a second cohort and was robust to both sampling methods and age.

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Published In

Nature neuroscience

DOI

EISSN

1546-1726

ISSN

1097-6256

Publication Date

September 2014

Volume

17

Issue

9

Start / End Page

1153 / 1155

Related Subject Headings

  • Young Adult
  • Serotonin Plasma Membrane Transport Proteins
  • Promoter Regions, Genetic
  • Predictive Value of Tests
  • Neurology & Neurosurgery
  • Models, Neurological
  • Male
  • Magnetic Resonance Imaging
  • Linear Models
  • Humans
 

Citation

APA
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ICMJE
MLA
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Nikolova, Y. S., Koenen, K. C., Galea, S., Wang, C.-M., Seney, M. L., Sibille, E., … Hariri, A. R. (2014). Beyond genotype: serotonin transporter epigenetic modification predicts human brain function. Nature Neuroscience, 17(9), 1153–1155. https://doi.org/10.1038/nn.3778
Nikolova, Yuliya S., Karestan C. Koenen, Sandro Galea, Chiou-Miin Wang, Marianne L. Seney, Etienne Sibille, Douglas E. Williamson, and Ahmad R. Hariri. “Beyond genotype: serotonin transporter epigenetic modification predicts human brain function.Nature Neuroscience 17, no. 9 (September 2014): 1153–55. https://doi.org/10.1038/nn.3778.
Nikolova YS, Koenen KC, Galea S, Wang C-M, Seney ML, Sibille E, et al. Beyond genotype: serotonin transporter epigenetic modification predicts human brain function. Nature neuroscience. 2014 Sep;17(9):1153–5.
Nikolova, Yuliya S., et al. “Beyond genotype: serotonin transporter epigenetic modification predicts human brain function.Nature Neuroscience, vol. 17, no. 9, Sept. 2014, pp. 1153–55. Epmc, doi:10.1038/nn.3778.
Nikolova YS, Koenen KC, Galea S, Wang C-M, Seney ML, Sibille E, Williamson DE, Hariri AR. Beyond genotype: serotonin transporter epigenetic modification predicts human brain function. Nature neuroscience. 2014 Sep;17(9):1153–1155.

Published In

Nature neuroscience

DOI

EISSN

1546-1726

ISSN

1097-6256

Publication Date

September 2014

Volume

17

Issue

9

Start / End Page

1153 / 1155

Related Subject Headings

  • Young Adult
  • Serotonin Plasma Membrane Transport Proteins
  • Promoter Regions, Genetic
  • Predictive Value of Tests
  • Neurology & Neurosurgery
  • Models, Neurological
  • Male
  • Magnetic Resonance Imaging
  • Linear Models
  • Humans