Treatment of postvitrectomy fibrin formation with intraocular tissue plasminogen activator.

Journal Article (Journal Article)

Twenty-five micrograms of human recombinant tissue plasminogen activator (tPA) was injected intracamerally into the eyes of three aphakic patients who developed severe intraocular fibrin formation within 24 hours after vitrectomy surgery. Fluid obtained from gas-fluid exchange specimens taken 24 hours after tPA injection was analyzed for tPA by an enzyme-linked immunosorbent assay and a spectrophotometric solid-phase fibrin assay. In each of the three patients, complete fibrin resolution occurred within four hours after the tPA injection. There were no complications associated with the intraocular tPA injections. There was measurable tPA activity 24 hours after the initial injection ranging from 0.23 to 1.4 micrograms. In contrast, tPA was undetectable in gas-fluid exchange specimens obtained from seven patients who did not receive intraocular tPA injections. Intraocular tPA is an effective means of treating postvitrectomy fibrin formation in selected aphakic patients.

Full Text

Duke Authors

Cited Authors

  • Williams, GA; Lambrou, FH; Jaffe, GA; Snyder, RW; Green, GD; Devenyi, RG; Abrams, GW

Published Date

  • August 1988

Published In

Volume / Issue

  • 106 / 8

Start / End Page

  • 1055 - 1058

PubMed ID

  • 3135790

International Standard Serial Number (ISSN)

  • 0003-9950

Digital Object Identifier (DOI)

  • 10.1001/archopht.1988.01060140211025


  • eng

Conference Location

  • United States