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Treatment of postvitrectomy fibrin formation with intraocular tissue plasminogen activator.

Publication ,  Journal Article
Williams, GA; Lambrou, FH; Jaffe, GA; Snyder, RW; Green, GD; Devenyi, RG; Abrams, GW
Published in: Arch Ophthalmol
August 1988

Twenty-five micrograms of human recombinant tissue plasminogen activator (tPA) was injected intracamerally into the eyes of three aphakic patients who developed severe intraocular fibrin formation within 24 hours after vitrectomy surgery. Fluid obtained from gas-fluid exchange specimens taken 24 hours after tPA injection was analyzed for tPA by an enzyme-linked immunosorbent assay and a spectrophotometric solid-phase fibrin assay. In each of the three patients, complete fibrin resolution occurred within four hours after the tPA injection. There were no complications associated with the intraocular tPA injections. There was measurable tPA activity 24 hours after the initial injection ranging from 0.23 to 1.4 micrograms. In contrast, tPA was undetectable in gas-fluid exchange specimens obtained from seven patients who did not receive intraocular tPA injections. Intraocular tPA is an effective means of treating postvitrectomy fibrin formation in selected aphakic patients.

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Published In

Arch Ophthalmol

DOI

ISSN

0003-9950

Publication Date

August 1988

Volume

106

Issue

8

Start / End Page

1055 / 1058

Location

United States

Related Subject Headings

  • Vitrectomy
  • Tissue Plasminogen Activator
  • Postoperative Complications
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Injections
  • Humans
  • Fibrinolysis
  • Fibrin
 

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Williams, G. A., Lambrou, F. H., Jaffe, G. A., Snyder, R. W., Green, G. D., Devenyi, R. G., & Abrams, G. W. (1988). Treatment of postvitrectomy fibrin formation with intraocular tissue plasminogen activator. Arch Ophthalmol, 106(8), 1055–1058. https://doi.org/10.1001/archopht.1988.01060140211025
Williams, G. A., F. H. Lambrou, G. A. Jaffe, R. W. Snyder, G. D. Green, R. G. Devenyi, and G. W. Abrams. “Treatment of postvitrectomy fibrin formation with intraocular tissue plasminogen activator.Arch Ophthalmol 106, no. 8 (August 1988): 1055–58. https://doi.org/10.1001/archopht.1988.01060140211025.
Williams GA, Lambrou FH, Jaffe GA, Snyder RW, Green GD, Devenyi RG, et al. Treatment of postvitrectomy fibrin formation with intraocular tissue plasminogen activator. Arch Ophthalmol. 1988 Aug;106(8):1055–8.
Williams, G. A., et al. “Treatment of postvitrectomy fibrin formation with intraocular tissue plasminogen activator.Arch Ophthalmol, vol. 106, no. 8, Aug. 1988, pp. 1055–58. Pubmed, doi:10.1001/archopht.1988.01060140211025.
Williams GA, Lambrou FH, Jaffe GA, Snyder RW, Green GD, Devenyi RG, Abrams GW. Treatment of postvitrectomy fibrin formation with intraocular tissue plasminogen activator. Arch Ophthalmol. 1988 Aug;106(8):1055–1058.

Published In

Arch Ophthalmol

DOI

ISSN

0003-9950

Publication Date

August 1988

Volume

106

Issue

8

Start / End Page

1055 / 1058

Location

United States

Related Subject Headings

  • Vitrectomy
  • Tissue Plasminogen Activator
  • Postoperative Complications
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Injections
  • Humans
  • Fibrinolysis
  • Fibrin