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Polymorphisms in MicroRNAs are associated with survival in non-small cell lung cancer.

Publication ,  Journal Article
Zhao, Y; Wei, Q; Hu, L; Chen, F; Hu, Z; Heist, RS; Su, L; Amos, CI; Shen, H; Christiani, DC
Published in: Cancer Epidemiol Biomarkers Prev
November 2014

BACKGROUND: MicroRNAs (miRNA) play important roles in the regulation of eukaryotic gene expression and are involved in human carcinogenesis. Single-nucleotide polymorphisms (SNP) in miRNA sequence may alter miRNA functions in gene regulation, which, in turn, may affect cancer risk and disease progression. METHODS: We conducted an analysis of associations of 142 miRNA SNPs with non-small cell lung cancer (NSCLC) survival using data from a genome-wide association study (GWAS) in a Caucasian population from the Massachusetts General Hospital (Boston, MA) including 452 early-stage and 526 late-stage NSCLC cases. Replication analyses were further performed in two external populations, one Caucasian cohort from The University of Texas MD Anderson Cancer Center (Houston, TX) and one Han Chinese cohort from Nanjing, China. RESULTS: We identified seven significant SNPs in the discovery set. Results from the independent Caucasian cohort demonstrated that the C allele of rs2042253 (hsa-miRNA-5197) was significantly associated with decreased risk for death among the patients with late-stage NSCLC (discovery set: HR, 0.80; P = 0.007; validation set: HR, 0.86; P = 0.035; combined analysis: HR, 0.87; P = 0.007). CONCLUSIONS: These findings provide evidence that some miRNA SNPs are associated with NSCLC survival and can be used as predictive biomarkers. IMPACT: This study provided an estimate of outcome probability for survival experience of patients with NSCLC, which demonstrates that genetic factors, as well as classic nongenetic factors, may be used to predict individual outcome.

Duke Scholars

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

November 2014

Volume

23

Issue

11

Start / End Page

2503 / 2511

Location

United States

Related Subject Headings

  • Prognosis
  • Polymorphism, Single Nucleotide
  • Polymorphism, Genetic
  • MicroRNAs
  • Male
  • Lung Neoplasms
  • Humans
  • Genome-Wide Association Study
  • Female
  • Epidemiology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhao, Y., Wei, Q., Hu, L., Chen, F., Hu, Z., Heist, R. S., … Christiani, D. C. (2014). Polymorphisms in MicroRNAs are associated with survival in non-small cell lung cancer. Cancer Epidemiol Biomarkers Prev, 23(11), 2503–2511. https://doi.org/10.1158/1055-9965.EPI-14-0389
Zhao, Yang, Qingyi Wei, Lingming Hu, Feng Chen, Zhibin Hu, Rebecca S. Heist, Li Su, Christopher I. Amos, Hongbing Shen, and David C. Christiani. “Polymorphisms in MicroRNAs are associated with survival in non-small cell lung cancer.Cancer Epidemiol Biomarkers Prev 23, no. 11 (November 2014): 2503–11. https://doi.org/10.1158/1055-9965.EPI-14-0389.
Zhao Y, Wei Q, Hu L, Chen F, Hu Z, Heist RS, et al. Polymorphisms in MicroRNAs are associated with survival in non-small cell lung cancer. Cancer Epidemiol Biomarkers Prev. 2014 Nov;23(11):2503–11.
Zhao, Yang, et al. “Polymorphisms in MicroRNAs are associated with survival in non-small cell lung cancer.Cancer Epidemiol Biomarkers Prev, vol. 23, no. 11, Nov. 2014, pp. 2503–11. Pubmed, doi:10.1158/1055-9965.EPI-14-0389.
Zhao Y, Wei Q, Hu L, Chen F, Hu Z, Heist RS, Su L, Amos CI, Shen H, Christiani DC. Polymorphisms in MicroRNAs are associated with survival in non-small cell lung cancer. Cancer Epidemiol Biomarkers Prev. 2014 Nov;23(11):2503–2511.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

November 2014

Volume

23

Issue

11

Start / End Page

2503 / 2511

Location

United States

Related Subject Headings

  • Prognosis
  • Polymorphism, Single Nucleotide
  • Polymorphism, Genetic
  • MicroRNAs
  • Male
  • Lung Neoplasms
  • Humans
  • Genome-Wide Association Study
  • Female
  • Epidemiology