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What can be learned from minimum 20-year followup studies of knee arthroplasty?

Publication ,  Journal Article
Callaghan, JJ; Martin, CT; Gao, Y; Pugely, AJ; Liu, SS; Goetz, DD; Kelley, SS; Johnston, RC
Published in: Clin Orthop Relat Res
January 2015

BACKGROUND: Long-term evaluation of knee arthroplasty should provide relevant information concerning the durability and performance of the implant and the procedure. Because most arthroplasties are performed in older patients, most long-term followup studies have been performed in elderly cohorts and have had low patient survivorship to final followup; the degree to which attrition from patient deaths over time in these studies might influence their results has been poorly characterized. QUESTIONS/PURPOSES: The purpose of this study was to examine the results at 20-year followup of two prospectively followed knee arthroplasty cohorts to determine the following: (1) Are there relevant differences among the two implant cohorts in terms of revision for aseptic causes (osteolysis, or loosening)? (2) How does patient death over the long followup interval influence the comparison, and do the comparisons remain valid despite the high attrition rates? METHODS: Two knee arthroplasty cohorts from a single orthopaedic practice were evaluated: a modular tibial tray (101 knees) and a rotating platform (119 knees) design. All patients were followed for a minimum of 20 years or until death (mean, 14.1 years; SD 5.0 years). Average age at surgery for both cohorts was >70 years. The indications for the two cohorts were identical (functionally limiting knee pain) and was surgeon-specific (each surgeon performed all surgeries in that cohort). Revision rates through a competing risks analysis for implants and survivorship curves for patients were evaluated. RESULTS: Both of these elderly cohorts showed excellent implant survivorship at 20 years followup with only small differences in revision rates (6% revision versus 0% revision for the modular tibial tray and rotating platform, respectively). However, attrition from patient deaths was substantial and overall patient survivorship to 20-year followup was only 26%. Patient survivorship was significantly higher in patients<65 years of age in both cohorts (54% versus 15%, p<0.001 modular tray cohort, and 52% versus 26%, p=0.002 rotating platform cohort). Furthermore, in the modular tray cohort, patients<65 years had significantly higher revision rates (15% versus 3%, p=0.0019). CONCLUSIONS: These two cohorts demonstrate the durability of knee arthroplasty in older patients (the vast majority older than 65 years). Unfortunately, few patients lived to 20-year followup, thus introducing bias into the analysis. These data may be useful as a reference for the design of future prospective studies, and consideration should be given to enrolling younger patients to have robust numbers of living patients at long-term followup. LEVEL OF EVIDENCE: Level III, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

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Published In

Clin Orthop Relat Res

DOI

EISSN

1528-1132

Publication Date

January 2015

Volume

473

Issue

1

Start / End Page

94 / 100

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Risk Factors
  • Retrospective Studies
  • Reoperation
  • Prosthesis Failure
  • Prosthesis Design
  • Osteolysis
  • Orthopedics
  • Middle Aged
 

Citation

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ICMJE
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Callaghan, J. J., Martin, C. T., Gao, Y., Pugely, A. J., Liu, S. S., Goetz, D. D., … Johnston, R. C. (2015). What can be learned from minimum 20-year followup studies of knee arthroplasty? Clin Orthop Relat Res, 473(1), 94–100. https://doi.org/10.1007/s11999-014-3744-1
Callaghan, John J., Christopher T. Martin, Yubo Gao, Andrew J. Pugely, Steve S. Liu, Devon D. Goetz, Scott S. Kelley, and Richard C. Johnston. “What can be learned from minimum 20-year followup studies of knee arthroplasty?Clin Orthop Relat Res 473, no. 1 (January 2015): 94–100. https://doi.org/10.1007/s11999-014-3744-1.
Callaghan JJ, Martin CT, Gao Y, Pugely AJ, Liu SS, Goetz DD, et al. What can be learned from minimum 20-year followup studies of knee arthroplasty? Clin Orthop Relat Res. 2015 Jan;473(1):94–100.
Callaghan, John J., et al. “What can be learned from minimum 20-year followup studies of knee arthroplasty?Clin Orthop Relat Res, vol. 473, no. 1, Jan. 2015, pp. 94–100. Pubmed, doi:10.1007/s11999-014-3744-1.
Callaghan JJ, Martin CT, Gao Y, Pugely AJ, Liu SS, Goetz DD, Kelley SS, Johnston RC. What can be learned from minimum 20-year followup studies of knee arthroplasty? Clin Orthop Relat Res. 2015 Jan;473(1):94–100.
Journal cover image

Published In

Clin Orthop Relat Res

DOI

EISSN

1528-1132

Publication Date

January 2015

Volume

473

Issue

1

Start / End Page

94 / 100

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Risk Factors
  • Retrospective Studies
  • Reoperation
  • Prosthesis Failure
  • Prosthesis Design
  • Osteolysis
  • Orthopedics
  • Middle Aged