Comparison of seven-day and repeated 24-hour recall of symptoms in the first 100 days after hematopoietic cell transplantation.

Journal Article (Journal Article)

CONTEXT: Patient-reported outcomes (PROs) provide a way to understand the effects of hematopoietic cell transplantation (HCT)-related stress on patients' lives. We previously reported that weekly collection of PROs is feasible. OBJECTIVES: Here, we report on the feasibility of daily patient-reported symptom collection and examine the relationship between daily vs. weekly symptom reporting over time. METHODS: We analyzed data from 32 autologous and allogeneic HCT patients obtained until Day (D) +100. We used questions from the PRO version of the Common Terminology Criteria for Adverse Events to capture symptoms. RESULTS: We found that overall rates of daily survey completion were moderate to high (range 67%-86%). The effect size of the difference between the maximum daily severity score and the weekly severity score ranged from 0.15 to 0.35, and the concordance correlation coefficient ranged from 0.513 to 0.834. Concordance of daily and weekly surveys was higher for maximum daily severity rating and mean daily severity rating than for minimum daily severity rating or most recent daily severity rating. CONCLUSION: We conclude that a seven-day recall period for symptom severity provides acceptable accuracy and precision in the first 100 days after HCT. Further studies to explore the utility of daily symptom reporting within specific clinical contexts may be warranted.

Full Text

Duke Authors

Cited Authors

  • Wood, WA; Deal, AM; Bennett, AV; Mitchell, SA; Abernethy, AP; Basch, E; Bailey, C; Reeve, BB

Published Date

  • March 2015

Published In

Volume / Issue

  • 49 / 3

Start / End Page

  • 513 - 520

PubMed ID

  • 25128608

Pubmed Central ID

  • PMC4326621

Electronic International Standard Serial Number (EISSN)

  • 1873-6513

Digital Object Identifier (DOI)

  • 10.1016/j.jpainsymman.2014.06.011


  • eng

Conference Location

  • United States