Skip to main content

Molecular imaging for depressive disorders.

Publication ,  Journal Article
Lee, T-S; Quek, SY; Krishnan, KRR
Published in: AJNR Am J Neuroradiol
June 2014

Molecular imaging is the visualization, characterization, and measurement of biologic processes at the molecular and cellular levels in humans and other living systems. Molecular imaging techniques such as MR spectroscopy and PET have been used to explore the molecular pathophysiology of depression and assess treatment responses. MR spectroscopy is a noninvasive technique that assesses the levels of biochemical metabolites in the brain, while PET uses radioligands injected in the bloodstream that have high binding affinity for target molecules. MR spectroscopy findings suggest a role for glutamate/glutamine and gamma-aminobutyric acid in depression. PET has generally failed to find a correlation between radioligand binding potential and depression severity or treatment response, though it may offer promise in distinguishing responders and nonresponders to treatment. A major challenge for both modalities is that depression is a heterogeneous, multifactorial disorder, while MR spectroscopy and PET are limited to examining a few metabolites or a single radioligand at a time. This difference makes a comprehensive evaluation of neurochemical changes in the brain difficult.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

AJNR Am J Neuroradiol

DOI

EISSN

1936-959X

Publication Date

June 2014

Volume

35

Issue

6 Suppl

Start / End Page

S44 / S54

Location

United States

Related Subject Headings

  • Positron-Emission Tomography
  • Nuclear Medicine & Medical Imaging
  • Molecular Imaging
  • Magnetic Resonance Spectroscopy
  • Humans
  • Depressive Disorder
  • Brain
  • 3406 Physical chemistry
  • 3209 Neurosciences
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lee, T.-S., Quek, S. Y., & Krishnan, K. R. R. (2014). Molecular imaging for depressive disorders. AJNR Am J Neuroradiol, 35(6 Suppl), S44–S54. https://doi.org/10.3174/ajnr.A3965
Lee, T. -. S., S. Y. Quek, and K. R. R. Krishnan. “Molecular imaging for depressive disorders.AJNR Am J Neuroradiol 35, no. 6 Suppl (June 2014): S44–54. https://doi.org/10.3174/ajnr.A3965.
Lee T-S, Quek SY, Krishnan KRR. Molecular imaging for depressive disorders. AJNR Am J Neuroradiol. 2014 Jun;35(6 Suppl):S44–54.
Lee, T. .. S., et al. “Molecular imaging for depressive disorders.AJNR Am J Neuroradiol, vol. 35, no. 6 Suppl, June 2014, pp. S44–54. Pubmed, doi:10.3174/ajnr.A3965.
Lee T-S, Quek SY, Krishnan KRR. Molecular imaging for depressive disorders. AJNR Am J Neuroradiol. 2014 Jun;35(6 Suppl):S44–S54.

Published In

AJNR Am J Neuroradiol

DOI

EISSN

1936-959X

Publication Date

June 2014

Volume

35

Issue

6 Suppl

Start / End Page

S44 / S54

Location

United States

Related Subject Headings

  • Positron-Emission Tomography
  • Nuclear Medicine & Medical Imaging
  • Molecular Imaging
  • Magnetic Resonance Spectroscopy
  • Humans
  • Depressive Disorder
  • Brain
  • 3406 Physical chemistry
  • 3209 Neurosciences
  • 3202 Clinical sciences